Preliminary analysis of qualitative changes in suspended red blood cells under different low-pressure and hypoxic conditions
10.13303/j.cjbt.issn.1004-549x.2023.01.004
- VernacularTitle:不同低气压缺氧环境下悬浮红细胞的质量变化
- Author:
Xuelian YONG
1
;
Li ZOU
2
;
Lei LIU
3
;
Qian ZANG
2
;
Jinxiu JI
2
;
Si CHENG
2
;
Yongqiang LI
2
Author Information
1. Department of Laboratory Medicine, Hospital of Jianghan University, Wuhan 430100, China
2. 95829 Military Hospital of PLA
3. Central Theater General Hospital of the Chinese People′s Liberation Army
- Publication Type:Journal Article
- Keywords:
suspended red blood cells;
blood delivery;
hypoxia/plateau
- From:
Chinese Journal of Blood Transfusion
2023;36(1):15-19
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To evaluate the quality of suspended red blood cells (SRBC) under low-pressure and hypoxic conditions, in order to lay a theoretical foundation for airline delivery, air drop and storage of SRBC on plateau. 【Methods】 The low-pressure and hypoxic conditions (0.026 MPa and 0.047 MPa) were simulated by a pressure control device. SRBC were divided into 3 groups (5 bags/group, 1.5 U/bag). Each group was stored in 0.026 MPa environment at 2℃-6℃ for 24 hours (named 0.026 MPa), in 0.047MPa environment at 2℃-6℃ for 7 days (named 0.047 MPa), and in a blood storage refrigerator at 4℃ (named the control), respectively. The storage cell characteristics were examined on day 2, 9, 14, 28 and 35. 【Results】 We found that HCT, MCV, K+, Na+, FHb, hemolytic ratio, 2, 3-DPG and rheological properties in group 0.026 MPa and 0.047 MPa were not significant different compared with that in control (P>0.05). The consumptions of Glu in group 0.026 MPa and 0.047 MPa were significantly higher (P<0.05), and a transient increase in LAC concentration of group 0.026 MPa and 0.047MPa were observed, compared to the control. 【Conclusion】 The conditions of low-pressure and hypoxia have no significant effect on the quality of suspended red blood cells.
