Blood donors with HBV core anti-body: a follow-up study
10.13303/j.cjbt.issn.1004-549x.2023.02.011
- VernacularTitle:核心抗体阳性献血者的跟踪研究
- Author:
Lu ZHOU
1
;
Dong WANG
1
;
Liang ZANG
1
;
Xuelian DENG
1
Author Information
1. Dalian Blood Center, Dalian 116001, China
- Publication Type:Journal Article
- Keywords:
occult hepatitis B virus infection;
antibody to hepatitis B virus core antigen;
nucleic acid testing;
blood donor re-entry
- From:
Chinese Journal of Blood Transfusion
2023;36(2):141-144
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To evaluate the role of anti-HBc detection in current blood screening strategy by the follow-up of repeated donors with antibody to hepatitis B virus core antigen. 【Methods】 Plasma samples were collected randomly from Dalian Blood Center. to test anti-HBc(dual reagents) and anti-HBs via ELISA. The re-donation of eligible donors who were anti-HBc+ and donors reactive to HBV detection were followed up. 【Results】 A total of 1 291 plasma samples were collected randomly from May 2017 to March 2018, among which 405 samples(31.4%)were anti-HBc+. The median age of anti-HBc+ group was observed much higher than that of anti-HBc-group (39 vs 31 years old) (P<0.05), but no significant difference was noticed in gender nor the proportion of first-time/repeated blood donors (P>0.05). Among the 405 anti-HBc+ donors, 3 donors were OBI (0.7%), of which one was screened out in second donation. No HBV DNA was detected out in 3 OBI cases. 【Conclusion】 Although anti-HBc detection is not suitable in blood screening currently, it is of great value in the assessment of blood donor re-entry for HBV reactive donors in blood screening due to the high anti-HBc prevalence among blood donors.
