Study on the change of neutralizing antibody level in plasma donors after a third shot of inactivated novel coronavirus vaccine
10.13303/j.cjbt.issn.1004-549x.2023.05.009
- VernacularTitle:献浆人群接种第3剂次新型冠状病毒灭活疫苗后中和抗体水平变化研究
- Author:
Wenjuan GE
1
;
An ZHOU
1
;
Junying SHEN
1
;
Xiaoqing LI
1
;
Jie MA
1
;
Mengzhao ZHU
1
;
Changyong JIAN
1
Author Information
1. Shandong Taibang Biological Products Co., Ltd, Tai’an 271000, China
- Publication Type:Journal Article
- Keywords:
inactivated novel coronavirus vaccine;
ELISA kit screening;
changes in neutralizing antibody titer level
- From:
Chinese Journal of Blood Transfusion
2023;36(5):410-415
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the trend of neutralizing antibody level in plasma donors who received the 3rd shot of inactivated novel coronavirus vaccine. 【Methods】 Three commercial ELISA kits for novel coronavirus neutralization antibody detection, manufactured by Company A, B and C, were chosen and screened by Pseudotype Neutralization Test from December 2021 to June 2022. A total of 410 plasma samples from 64 plasma donors who received the 3rd shot of inactivated novel coronavirus vaccine and there after donated plasma within six months were detected by the selected ELISA kit from July to October, 2022. The data were analyzed by Excel 2013 and SPSS 26 software. 【Results】 The high-throughput ELISA kit for SARS-CoV-2 neutralizing antibody detection, manufactured by Company A, was selected for further antibody titer detection. The mixed plasma titers were 1 337.34, 1 148.89, 852.19, 681.38, 556.44 and 457.19 U/mL from 1 to 6 months, respectively, after the 3rd shot of vaccine. The neutralizing antibody titer level began to increase around 7 days after the 3rd shot of vaccine injection and peaked (peak range: 264.07-2 208.39 U/mL, median: 569.34 U/mL) at 1 month (range: 9-43 days, median: 22 days), and then gradually decreased (P<0.05). 【Conclusion】 The neutralizing antibody titer of plasma donors who received the 3rd shot of inactivated novel coronavirus vaccine began to rise around 7 days after vaccination, which reached the peak value at around 1 month and then gradually decreased.
