Effect of recombinant human coagulation factor Ⅶa combined with Bakri balloon compression on oxidative stress and coagulation in patients with refractory postpartum hemorrhage
10.13303/j.cjbt.issn.1004-549x.2023.06.013
- VernacularTitle:重组人凝血因子Ⅶa联合Bakri球囊压迫对难治性产后出血预后相关指标的影响
- Author:
Jiaqi LI
1
;
Lan LI
1
;
Lu ZHANG
1
;
Mingsheng LIU
1
;
Youwen MEI
2
Author Information
1. Chengdu Fifth People′s Hospital, Chengdu 611130, China
2. Chengdu Women’s and Children′s Central Hospital
- Publication Type:Journal Article
- Keywords:
refractory postpartum hemorrhage;
recombinant human coagulation factor Ⅶa;
Bakri balloon compression;
oxidative stress;
coagulation function
- From:
Chinese Journal of Blood Transfusion
2023;36(6):512-515
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the effects of recombinant human coagulation factor Ⅶa combined with Bakri balloon compression on oxidative stress and coagulation in patients with refractory postpartum hemorrhage. 【Methods】 Prospectively, 80 patients with refractory postpartum hemorrhage in Chengdu Fifth People′s Hospital from June 2019 to June 2022 were selected and grouped according to the random number table method. The control group (n=40) was treated with Bakri balloon compression, and the observation group (n=40) was treated with recombinant human coagulation factor Ⅶa combined with Bakri balloon compression. The bleeding-related indexes and adverse effects were observed in both groups, and the prenatal and 24 h postpartum oxidative stress, coagulation function and inflammatory factors were compared between the two groups. 【Results】 The blood loss in the observation group and the control group was (683.96±146.52) vs(796.63±152.41)mL during operation, (812.46±161.53) vs(965.39±166.22)mL in 2 h after delivery, (899.53±178.74) vs(1 084.31±203.67)mL in 24 h after delivery, and the transfusion volume was (512.31±104.76) vs(683.25±113.52)mL, and the onset time of hemostasis was (14.63±3.18) vs (21.72±5.29) min (P<0.05); the difference in the incidence of adverse reactions between the two groups was not significant (P>0.05). At 24 h postpartum, NE, Cor, SOD and MDA were higher than those before delivery in both groups, but the observation group was lower than the control group (P<0.05); TT, APTT and PT were longer and Fib was lower in both groups than before delivery, but TT, APTT and PT were shorter and Fib was higher in the observation group than in the control group (P<0.05); CRP, IL-8 and TNF-α were higher in both groups than before delivery, but the observation group was lower than in the control group (P<0.05). 【Conclusion】 Hemostasis in patients with refractory postpartum hemorrhage treated with recombinant human coagulation factor Ⅶa combined with Bakri balloon compression was effective, which can improve coagulation, reduce transfusion, decrease oxidative stress injury and inflammatory response without increasing adverse effects.
