Investigation on the prevalence of human parvovirus B19 infection among voluntary blood donors
10.13303/j.cjbt.issn.1004-549x.2023.07.016
- VernacularTitle:无偿献血人群人微小病毒B19感染状况调查
- Author:
Rong LU
1
;
Xueqiong ZHENG
1
;
Zihao XU
1
;
Longhai TANG
1
;
Mingyuan WANG
1
;
Yiming JIN
1
Author Information
1. Suzhou Blood Center, Suzhou 215000, China
- Publication Type:Journal Article
- Keywords:
human parvovirus B19;
voluntary blood donors;
serological detection;
epidemiology
- From:
Chinese Journal of Blood Transfusion
2023;36(7):622-626
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the infection of human parvovirus B19 in Suzhou voluntary blood donors under the current blood screening model. Methods A total of 893 blood donor samples from September to December 2022 were randomly collected. Samples were tested to determine the seroprevalence (anti-B19 IgG and IgM) of B19 antibodies by enzyme-linked immunosorbent assay(ELISA), and B19 DNA of positive samples was further detected by real-time polymerase chain reaction(PCR) assay. Results Among 893 samples, the total seroprevalence of B19 antibody was 20.7% (185/893), with anti-B19 IgG and IgM positive rate at 19.4% (173/893) and 1.9% (17/893), respectively, showing significant difference (P<0.05). No difference in the positive rates of B19 IgG and IgM (20.1%, 1.5% vs 18.0%,2.6%) was noticed by gender(P>0.05). The prevalence of anti-B19 IgG statistically increased with age (P<0.05), while there was no difference in the prevalence of anti-B19 IgM (P>0.05). No statistical difference was not found in anti-B19 IgG and IgM samples among different blood groups. The anti-B19 IgG in repeated blood donors was higher than that in first-time donors(21.5% vs 15.9%)(P<0.05) while there was no difference in the positive rate of IgM antibodies (P>0.05). Three cases were found to be positive for B19 DNA in the B19 antibody positive samples, with the positive rate at 1.6%(3/185). Conclusion Although the prevalence of B19 infection in Suzhou was lower than that in other areas and was mostly past infection, there was still a certain proportion of persistent infection and acute infection, which posed the potential risk of blood transfusion transmission. Therefore, attention should be paid to blood transfusions, especially for the high-risk and susceptible groups.
