Blood immunological analysis of hemolytic disease of the fetus and newborn caused by Rh deletion type D--
10.13303/j.cjbt.issn.1004-549x.2023.07.010
- VernacularTitle:RhD--表型引起的胎儿新生儿溶血病的免疫学分析——附1例报道
- Author:
Yiman ZHAO
1
;
Libo BI
1
;
Xuhua YANG
1
;
Xiaoya YANG
1
;
Shengru XU
1
;
Surui LIU
1
,
2
Author Information
1. Department of Blood Transfusion Medicine, the No. 980 Hospital of Joint Logistics Support Force in People's Liberation Army, Shijiazhuang 050082, China
2. Laboratory Pathology Department, Sanya Rehabilitation Center of Joint Logistics Support Force
- Publication Type:Journal Article
- Keywords:
Rh deletion type D--;
hemolytic disease of the fetus and newborn(HDFN);
genetic testing;
variant
- From:
Chinese Journal of Blood Transfusion
2023;36(7):598-600
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To analyze the causes of a case of hemolytic disease of the fetus and newborn (HDFN),and investigate the genetic background of maternal Rh deletion D--formation. 【Methods】 Blood samples of maternal and fetus were collected, and ABO blood typing, Rh blood typing, antibody screening and identification test were performed to explore the blood group serological characteristics of Rh deletion type D--, and Rh gene sequence was performed on parturient. 【Results】 The maternal blood group was identified to be O type, D--, and the anti-Hr0 antibody against Rh high-frequency antigen was suspected to be caused by multiple pregnancies which passes through the placental barrier and enable fetus to obtain anti Hr0 antibody, leading to HDFN, with genetic testing result as RH RHCE* Ce/RHCE* Ce. 【Conclusion】 In-depth research on the formation mechanism of Rh D-- in parturient should be conducted to provide clinical value for HDFN blood exchange treatment and blood transfusion in special blood group population.
