Influence of blood donors' coagulation status in apheresis platelet aggregation in vitro
10.13303/j.cjbt.issn.1004-549x.2023.08.018
- VernacularTitle:献血者凝血状态对其捐献的单采血小板体外聚集现象的影响
- Author:
Yujian LIU
1
;
Xiaofan LI
1
;
Qiwen LIN
1
;
Dawei CHEN
1
;
Fanfan FENG
1
;
Huibin ZHONG
1
;
Wenchun ZHANG
1
;
Yongmei NIE
1
Author Information
1. Guangzhou Blood Center, Guangzhou 510095, China
- Publication Type:Journal Article
- Keywords:
platelet aggregation in vitro;
coagulation status of blood donors;
apheresis platelet;
coagulation index(CI);
platelet parameters;
blood cell separator
- From:
Chinese Journal of Blood Transfusion
2023;36(8):728-731
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate whether the blood donors' coagulation status may lead to apheresis platelet aggregation in vitro. 【Methods】 Thirty blood donors with aggregation in apheresis platelets collected by AMICUS blood cell separator no less than 3 times previously and occurred when the last time of apheresis donation were observed in aggregated group (referred to as the experimental group); Thirty donors without aggregation in apheresis platelets collected by AMICUS blood cell separator no less than 3 times were observed in the control group simultaneously. The basic platelet parameters in the two groups, including Plt, MPV, PDW, Pet, P-LCR were detected by automatic blood cell analyzer (BC-3000Plus), and thromboelastogram indexes including reaction time(R), kinetics time(K), kinetics of clot development(α), maximum amplitude (MA) and coagulation index(CI) were tested by Thrombosis elastography (TEG) before collection. With SPSS24.0 software, t test was used to compare the differences between the two groups. 【Results】 The CI value in experimental group was significantly different from that of the control group (0.48± 1.00 vs -0.99 ±1.96, P< 0.05), and there was no significant difference in all above basic platelet parameters and other TEG parameters (P>0.05 ) . 【Conclusion】 The coagulation status of blood donors may be an independent risk factor for the in vitro aggregation of apheresis platelets.
