Analysis of blood component transfusion and some adverse reactions in myelodysplastic syndroms patients
10.13303/j.cjbt.issn.1004-549x.2023.08.008
- VernacularTitle:骨髓增生异常综合征成分输血及部分输血反应分析
- Author:
Wenhao XU
1
;
Youshan ZHAO
2
;
Chao XIAO
2
;
Chunkang CHANG
2
Author Information
1. Department of Blood Transfusion, Shanghai Sixth People's Hospital affliated to Shanghai Jiaotong University School oj Medicine, Shanghai 200233 , China
2. Department of Hematology, Shanghai Sixth People's Hospital affliated to Shanghai Jiaotong University School oj Medicine, Shanghai 200233 , China
- Publication Type:Journal Article
- Keywords:
myelodysplasic neoplasms (MDS);
blood component transfusion;
adverse reactions to blood transfusion;
delayed serologic transfusion reaction (DSTR)
- From:
Chinese Journal of Blood Transfusion
2023;36(8):689-693
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To analyze the blood transfusion and adverse reactions in myelodysplastic syndroms (MDS) patients, so as to improve transfusion management in MDS patients. 【Methods】 The diagnosis and treatment information of MDS patients with blood transfusion in our hospital from January 2003 to December 2022 were collected, and the component transfusion and adverse reactions were investigated. 【Results】 The average infusion volume of red blood cells(RBCs) and platelets were respectively (27.46±43.11 ) and (16.41±24.81 ) in 799 MDS patients, which had no correlation with gender and blood type. The incidence of adverse reactions was 18.27% (146/799), with the most common adverse reactions as delayed serologic transfusion reaction (DSTR) (9.01%, 72/799), followed by non hemolytic fever reaction (4.76%, 38/799) and allergic reaction (4.38%, 35/799). Compared with all patients with transfusion, DSTR was more common in females (P<0.05), with elder age and had more RBCs consumption (all P<0.01). 86.11%(62/72) were Rh system, and 40.28% (29/72) had 2 or more antibodies. The occurrence time of DSTR in some patients was not related to the volume of RBCs trans infusion. 【Conclusion】 MDS patients, with more average transfusion volume and higher incidence of adverse reactions especially DSTR, were recommended a strictly limited transfusion schedule and Rh phenotype matching RBC products. The investigation of immune status of MDS patients at different periods is helpful to provide new aspects and therapeutic measures for the pathogenesis of DSTR, and the antibody screening time may adjusted appropriately.
