Cellular and humoral immune status of thalassemia children with repeated blood transfusion in Yunnan province
10.13303/j.cjbt.issn.1004-549x.2023.09.006
- VernacularTitle:云南地区反复输血的地中海贫血儿童细胞免疫和体液免疫状态的研究
- Author:
Xiaohong JIN
1
;
Rui CHEN
1
;
Shuxia WANG
1
;
Jianxiang LIU
1
;
Lilan GAO
1
;
Mengxing LYU
1
;
Kexuan QU
1
Author Information
1. Kunming Health Commission Technology Center, Yunnan Clinical Research Center of Children Health and Disease, Kunming Children's Hospital, Kunming 650228, China
- Publication Type:Journal Article
- Keywords:
children with thalassemia;
repeated blood transfusion;
lymphocyte subsets;
humoral immunity;
Yunnan
- From:
Chinese Journal of Blood Transfusion
2023;36(9):782-786
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the changes in cellular immunity (peripheral blood lymphocyte subsets) and humoral immunity (serum immunoglobulin and ferritin) status among children with thalassemia who received repeated transfusions in Yunnan. 【Methods】 Forty-six children with thalassemia who underwent repeated blood transfusions from January 2020 to October 2022 were selected as the observation group. Forty children with thalassemia who did not receive blood transfusion were included in control group 1, and 46 healthy children underwent physical examination were included in control group 2. The differences in lymphocyte subsets, serum immunoglobulin levels and ferritin concentrations were compared among the three groups. 【Results】 For lymphocyte subsets: CD3+, CD4+ and CD4+/CD8+ in the observation group was lower than the control group 1 and 2: 57.60±8.36 vs 64.57±7.56 vs 66.58±5.65, 33.16±5.67 vs 38.62±8.36 vs 38.62±6.41 and 1.49±0.09 vs 2.32±0.15 vs 2.13±0.16, respectively; CD16+ CD56+ in the observation group was lower than the control group 2: 11.21±5.06 vs 16.70±7.92; CD8+ in the observation group was higher than control group 1 and control group 2: 26.63± 1.75 vs 20.60±1.43 vs 18.92±0.84; CD19+ in the observation group was higher than the control group 2: 24.06±6.42 vs 19.67 ±8.42, P<0.05, but no significant difference was noticed between the two control groups(P>0.05). For serum immunoglobulin and ferritin: IgG and ferritin in the observation group were higher than control group 1 and control group 2: 10.59±3.88 vs 7.02±3.88 vs 5.58±1.98 and 2 037.37±1 377.59 vs 72.63±56.71 vs 59.48±33.88. IgA in the observation group was higher than the control group 2: 1.06±0.92 vs 0.39±0.32(P<0.05), but no significant difference was noticed between the two control groups (P>0.05). The difference of IgM and IgE between the three groups was not significant (P > 0. 05). 【Conclusion】 The proportion of lymphocyte subsets in thalassemia children with repeated blood transfusion was imbalanced,and the level of immunoglobulin in humoral immunity was abnormal.
