Analysis of related factors of plasma antibody titer in convalescent patients with COVID-19
10.13303/j.cjbt.issn.1004-549x.2023.09.004
- VernacularTitle:新冠病毒感染患者恢复期血浆抗体效价的相关因素分析
- Author:
Xin HU
1
;
Hua XU
1
;
Na FENG
1
;
Jin DING
1
;
Fengqin LI
1
Author Information
1. Shaanxi Blood Center, Xi'an 710000, China
- Publication Type:Journal Article
- Keywords:
COVID-19 convalescent plasma;
IgG, IgM;
neutralizing antibody
- From:
Chinese Journal of Blood Transfusion
2023;36(9):774-776
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To study the relationship between the plasma IgG, IgM, neutralizing antibody titer and sex, age, collection interval in convalescent patients with COVID-19, so as to guide the plasma collection of convalescent patients with COVID-19. 【Methods】 COVID-19 convalescent plasma was collected to determine the antibody titer, and the difference and correlation of data in each group were analyzed by SPSS statistical analysis software. 【Results】 The median titers (AU/mL)of IgG, IgM and neutralizing antibodies in males and females were 484.24 vs 516.04, 2.13 vs 1.73, and 1 124.74 vs 1 143.99, respectively, and there was no significant difference(P>0.05) . Age had weak positive correlation with IgG and neutralizing antibody, and the Spearman correlation coefficient was 0.188 (P<0.05). The median titers (AU/mL) of IgG, IgM and neutralizing antibody at first donation of 30 repeated donors were 522.3, 2.64 and 1 174.6, respectively, but at second donation were 332.08, 0.63 and 708.96, showing significant difference (P<0.05). 【Conclusion】 There was no significant difference in the plasma IgG, IgM and neutralizing antibody titers in convalescent COVID-19 patients of different ages and genders, and the titers met the requirements of clinical treatment guidelines. Although the plasma antibody level of repeated donors has decreased, it still has clinical value.
