Exploration of the relationship between the storage time of leukodepleted red blood cell and transfusion adverse reactions
10.13303/j.cjbt.issn.1004-549x.2023.10.008
- VernacularTitle:去白红细胞储存时间与输血反应关系探讨
- Author:
Liu HE
1
;
Jian LIU
2
;
Gang WU
3
;
En WANG
4
;
Fayan YI
5
;
Xingshun TAN
2
;
Shiyu ZHU
2
;
Rui YU
2
;
Guanghui LU
6
;
Yan LIU
6
;
Mei ZHAI
2
;
Qing XIANG
2
;
Ping LIU
2
;
Yanhua LIAO
2
;
Zhizhen FU
2
;
Maolin LI
2
;
Rong HUANG
2
Author Information
1. Key Laboratory of Transfusion Adverse Reactions, Chinese Academy of Medical Sciences, Institute of Blood Transfusion, Chinese Academy of Medical Sciences& Peking Union Medical College, Chengdu 610052, China
2. The People’s Hospital of Jianshi
3. The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
4. The People’s Hospital of Xuanen
5. Xianfeng County People’s Hospital
6. Minda Hospital of Hubei Minzu University
- Publication Type:Journal Article
- Keywords:
leukodepleted red blood cells;
transfusion adverse reaction;
storage time;
non hemolytic febrile reaction;
allergic reaction
- From:
Chinese Journal of Blood Transfusion
2023;36(10):889-891
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the relationship between the storage time of leukodepleted red blood cells and transfusion adverse reactions by analyzing the occurrence of transfusion adverse reactions of patients after leukodepleted red blood cells transfusion from four hospitals. 【Methods】 By using the electronic medical record management system, the collection and transfusion dates of leukodepleted red blood cells from four hospitals in Enshi Prefecture from 2018 to 2022, as well as the information on transfusion adverse reactions, were retrieved. 【Results】 From 2018 to 2022, a total of 697 61 bags of leukodepleted red blood cells were transfused in four hospitals, resulting in 166 cases of transfusion adverse reactions, among which 93 were allergic reactions, 63 were non hemolytic febrile reactions, and 10 were others, with a total incidence rate of transfusion adverse reactions at 0.24%. The average storage time of leukodepleted red blood cells with and without transfusion adverse reactions was (20.25±6.31) and (19.88±5.50) days, respectively. With a storage time of 7 days as the threshold, the incidence of transfusion adverse reactions was the lowest for a storage time of 15~21 days. The incidence of transfusion adverse reactions of leukodepleted red blood cells in two groups (with storage days ≤21 days and >21 days) was not statistically significant(P>0.05). 【Conclusion】 Allergic reactions were the main type of transfusion adverse reaction caused by leukodepleted red blood cells, and the incidence of transfusion adverse reactions decreased and then increased with the prolongation of the storage time of leukodepleted red blood cells. There was no significant difference in the incidence of transfusion adverse reactions with leukodepleted red blood cells stored for ≤ 21 days and >21 days.
