Study on transfusion-related acute lung injury caused by HLA-Ⅱ antibody
10.13303/j.cjbt.issn.1004-549x.2023.10.007
- VernacularTitle:HLA-Ⅱ类抗体引起输血相关性急性肺损伤———附2例报告
- Author:
Yu ZOU
1
;
Mao ZHENG
1
;
Xin JI
2
;
Xiuyun LIAO
3
;
Tianhua JIANG
1
;
Jue WANG
2
Author Information
1. Department of Blood Transfusion,Deyang People′s Hospital, Deyang 618000, China
2. Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College
3. Deyang Central Blood Station
- Publication Type:Journal Article
- Keywords:
transfusion-related acute lung injury(TRALI);
platelets;
HLA antibodies
- From:
Chinese Journal of Blood Transfusion
2023;36(10):885-888
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the risk factors of transfusion-related acute lung injury (TRALI). 【Methods】 The clinical symptoms, signs, imaging examinations, and laboratory test results of two patients with TRALI after blood transfusion were retrospectively analyzed, and human leukocyte antigen (HLA) genotyping of the patient and HLA antibodies typing of the plasma donors were performed. 【Results】 The clinical manifestations and laboratory parameters of two patients were consistent with those of TRALI after blood transfusion. After timely clinical respiratory support treatment, all patients were improved. Blood donors produced high titers of HLA-Ⅱ antibodies after pregnancy, including antibodies that specifically recognize the patient′s HLA antigen. 【Conclusion】 Two patients developed TRALI after platelet transfusion from a female blood donor, which was caused by HLA-Ⅱ antibodies.
