Identification of immune hemolytic transfusion reaction and exploration of transfusion compatibility testing
10.13303/j.cjbt.issn.1004-549x.2023.11.023
- VernacularTitle:免疫性溶血性输血反应的鉴定分析及输血相容性检测探讨
- Author:
Xiujuan JIAO
1
;
Zhuan LIU
1
;
Hongliang HUANG
1
Author Information
1. Yancheng Blood Center, Yancheng 224005, China
- Publication Type:Journal Article
- Keywords:
hemolytic transfusion reaction;
Rh blood group;
unexpected antibody;
anti-E;
anti-c
- From:
Chinese Journal of Blood Transfusion
2023;36(11):1064-1067
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To analyze the causes of immune hemolytic transfusion reaction in one case, identify related antibodies, and explore transfusion compatibility testing. 【Methods】 ABO/Rh blood group identification, unexpected antibody identification of serum and diffusion fluid, direct antiglobulin test(DAT) and cross matching were conducted by saline method and/or microcolumn gel method. 【Results】 The patient′s blood group was O, and Rh phenotype was identified as DCCee. The DAT was negative, with strong anti-E antibody and weak anti-c antibody detected. Acute hemolytic transfusion reaction occurred in the patient after the last transfusion. 【Conclusion】 Currently, immune hemolytic transfusion reaction in China are mainly caused by Rh blood group system antibodies. The absence of unexpected antibody screening before blood transfusion and the weak anti-c antibody which resulted in missed detection of non compatibility in cross matching led to acute hemolytic transfusion reaction. It is recommended to conduct unexpected antibody screening before blood transfusion, and to collect blood sample for testing as soon as possible to improve the accuracy of DAT when acute hemolytic transfusion reaction is suspected.
