A Case of Successful Treatment of Cervical Pregnancy with Methotrexate and Leucovorin.
- Author:
Kang Joo BAEK
;
Dong Ryool LIM
;
P S PACK
;
Koe Seung YANG
;
Ho Soon JUNG
- Publication Type:Original Article
- Keywords:
Cervical pregnancy;
Methotrexate;
Leucovorin;
Ultrasonography;
Fertility
- MeSH:
Drug Therapy;
Early Diagnosis;
Fertility;
Follow-Up Studies;
Humans;
Leucovorin*;
Methotrexate*;
Pregnancy*;
Ultrasonography;
Uterine Hemorrhage;
Uterus
- From:Korean Journal of Perinatology
1997;8(1):70-78
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Until recently, the cervical pregnancy have been treated with surgery, usually hy- sterectomy, because of uncontrollable heavy vaginal bleeding. The development of sophisticated ultrasound which allows early diagnosis of cervical pregnancy and methotrexate chemotherapy opened up new therapeutic options in the management of this unusual but potentially life threatening complication of pregnancy which have been always a nightrnare for the gynecologist. We are reporting a case of cervical pregnancy diagnosed in 12 weeks of gestation. The patient was successfully treated with alternative administration of methotrexate (1 mg/kg, intramuscularly) and leucovorin (0.1 mg/kg, intramuscularly) without surgical intervention, in order to preserve both the uterus and fertility. Follow up was done with serum beta hCG and pelvic ultrasonography. Complete resolution of the cervical pregnancy was obtained at 50 days after starting methotrexate treatment. This case gave us the opportunity to review the recent literature on cervical pregnancy.
