Three new anthraquinones from Prismatomeris tetrandra (Roxb.) K. Schum and their protective effects in neuroblastoma cells
10.16438/j.0513-4870.2023-1104
- VernacularTitle:黄根中3个新蒽醌类化合物及其对神经细胞的保护作用
- Author:
Xin-yi CHEN
1
;
Chen ZHANG
2
;
Yi-rong DONG
1
;
Ying-da ZANG
1
;
Jia-qi CHEN
1
;
Hong-tao JIN
2
,
3
;
Dong-ming ZHANG
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Beijing Union-Genius Pharmaceutical Technology Development Co., Ltd., Beijing 100176, China
3. New Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
italic>Prismatomeris tetrandra;
chemical composition;
anthraquinone;
neuroprotection
- From:
Acta Pharmaceutica Sinica
2023;58(12):3710-3714
- CountryChina
- Language:Chinese
-
Abstract:
Three new anthraquinones were isolated from the 80% ethanol extract of Prismatomeris tetrandra by silica gel, MCI, ODS column chromatography and high performance preparative liquid chromatography (HPLC). The structures of the new compounds were identified by mass spectrometry, nuclear magnetic resonance and other spectroscopic methods as 6-hydroxy-1,2,3-trimethoxy-7-methylanthracene-9,10-dione (1), 6-(hydroxymethyl)-1,2,3-trimethoxyanthracene-9,10-dione (2) and 7-hydroxy-6-(hydroxymethyl)-1,2-dimethoxyanthracene-9,10-dione (3). Compounds 1, 2 and 3 showed protective effects against monosodium glutamate-induced damage in SH-SY5Y neuroblastoma cells, with the cell survival rates elevated 18.45%, 4.31%, and 7.65%, respectively.
