Monoterpenes and hexenol glycosides from an aqueous extract of Monochasma savatieri
10.16438/j.0513-4870.2023-0987
- VernacularTitle:鹿茸草水提取物中的单萜和己烯醇苷
- Author:
Chen LIU
1
;
Cheng-bo XU
1
;
Cheng-gen ZHU
1
;
Xiao-qiang LEI
1
;
Bin MU
2
;
Jian-gong SHI
1
;
Qing-lan GUO
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Harbin Kanglong Pharmaceutical Co., Ltd., Harbin 150025, China
- Publication Type:Research Article
- Keywords:
Scrophulariaceae;
italic>Monochasma savatieri;
aqueous extract;
monochaside I;
monochairidol
- From:
Acta Pharmaceutica Sinica
2023;58(12):3701-3709
- CountryChina
- Language:Chinese
-
Abstract:
Twelve compounds, including 5 new monoterpenes and 7 known derivatives, were isolated from a water decoction of Monochasma savatieri by column chromatography over macroporous adsorbent resin, MCI resin, Sephadex LH-20, and HW-40C, combined with preparative TLC, reversed phase HPLC, and flash column chromatographic techniques. Their structures were elucidated by comprehensive analysis of spectroscopic data, along with enzymatic hydrolysis as well as electronic circular dichroism (ECD) and NMR calculations, the new structures named monochaside I (1) and monochairidols A-D (2-5), respectively. The known compounds 6-12 were obtained from the Monochasma plants for the first time.
