Impact of multiple platelets donation on peripheral blood routine in regular blood donors
10.13303/j.cjbt.issn.1004-549x.2021.02.017
- VernacularTitle:多次捐献单采血小板固定献血者外周血常规的变化
- Author:
Yan HU
1
;
Yajuan WU
1
;
Junlong YANG
1
;
Li ZHANG
1
Author Information
1. Department of Blood Transfusion, General Hospital of Western Theater Command, Chengdu 610083, China
- Publication Type:Journal Article
- Keywords:
apheresis platelets;
peripheral blood routine;
impact
- From:
Chinese Journal of Blood Transfusion
2021;34(2):161-164
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the changes in peripheral blood routine in blood donors after multiple and frequent platelets donation. 【Methods】 A total of 228 voluntary blood donors who donated apheresis platelets for 5 or more times were selected. The results of peripheral blood routine testing before the first and most recent donation were collected. The data were analyzed in terms of blood donation volume, frequency of blood donation (total frequency/total months), and numbers of blood donation. 【Results】 1) There was statistical significance in the decrease of WBC counts when the accumulative volume of platelet donation >18 treatment doses and the number of blood donation >10 (P<0.05). 2) After self-compensating, the difference in RBC counts decrease was statistically significant as blood donation volume ≥36 treatment doses, blood donation frequency ≥1.4, and number of blood donation >18, (P<0.05). 3) There was statistical significance in the decrease of Hb when blood donation volume >18 treatment doses, blood donation frequency ≥1, and the number of blood donation >18(P<0.05). 4) The Plt value of most recent donation was significantly higher than the first one when blood donation volume was >18 treatment doses (P<0.05), then the gaps in Plt values shrank to marginal as the donation continued(P>0.05), and a significant lead in the Plt value of most recent donation was observed again until the blood donation volume reached ≥76 treatment doses (P<0.05). When the frequency of blood donation was >1.4 and the number of blood donations≥40, the Plt value of the most recent donation was significantly higher than that of the first one(P<0.05). 【Conclusion】 The indexes of peripheral blood in multiple donors were found to be fluctuating due to the frequent platelet donation, but still within the normal range. When platelet donation volume>18 treatment doses, blood donation frequency >1.4, and the number of donation >18, it is recommended to extend the donation interval and/or take iron supplements appropriately.
