Detection of antibiotic antibodies in 358 patients with anemia: comparative analysis of two methods
10.13303/j.cjbt.issn.1004-549x.2021.02.014
- VernacularTitle:两种方法检测358例贫血患者抗生素类药物性抗体结果分析
- Author:
Yangyang ZHENG
1
,
2
;
Feng CHEN
3
Author Information
1. Gradciate school, Baotou Medical College, Baotou 014010, China
2. Department of Clinical Transfusion, Inner Mongolia People′s Hospital
3. Department of Clinical Transfusion, Inner Mongolia People′s Hospital
- Publication Type:Journal Article
- Keywords:
drug-induced immune hemolytic anemia;
antibiotics;
drug-induced antibodies
- From:
Chinese Journal of Blood Transfusion
2021;34(2):150-153
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the frequency of antibiotic antibodies in hospitalized patients with anemia and analyze the yieldingresults. 【Methods】 The blood samples of 358inpatients with anemia, whohad taken antibiotics for 3 days or more, were selected. The drug-coated red blood cell method and drug addition method were used for the detection of antibodies toantibiotic drug, and the relevant clinical data were consulted for comprehensive analysis of the experimental results. 【Results】 Among the 358 blood samples, antibiotic antibodies were detectedin 12 by drug-coated red blood cell method, with ayielding rate of 3.35%(12/358). 6 out of 284 samples subjected to cephalosporin antibodies testing were positive, with a positive rate at 2.11%(6/284), and6 out of 74 samples subjected to non-cephalosporins antibodies testing were positive, with a positive rate at 8.11%(6/74), showingstatistical significance between the above two positive rates(P<0.05). No significant difference was notable among the 12 patients with positive antibioticantibody by gender, age, operation andnon-operation(P>0.05). No antibiotic antibodies were yielded in blood samples bydrug addition method. 【Conclusion】 The corresponding antibodiesagainst antibiotic could be produced insome patientsafter takingantibiotics.Therefore, enhancing the clinical attentionto antibiotic antibodies is of great significance to the effective application of clinical antibioticsand the accuracy of blood transfusion therapy.
