Effect of ABO blood group on coagulation factor Ⅷ activity and fibrinogen content in fresh plasma products
10.13303/j.cjbt.issn.1004-549x.2021.02.005
- VernacularTitle:新鲜血浆制剂凝血因子Ⅷ活性和纤维蛋白原含量与ABO血型相关性研究
- Author:
Jing LAN
1
;
Qinqin ZUO
1
;
Yuan ZHANG
1
;
Fengqin LI
1
;
Yali ZHANG
1
;
Hua XU
1
Author Information
1. Shaanxi Blood Center, Xian 710000, China
- Publication Type:Journal Article
- Keywords:
ABO blood group;
coagulation factor Ⅷ;
fibrinogen;
quality control;
quality standard
- From:
Chinese Journal of Blood Transfusion
2021;34(2):117-119
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 Tostudy the effect of ABO blood group on the FⅧ∶C and Fib content in human plasma, so as to provide the oretical guidance for the quality control of fresh plasma products and the establishment of relevant quality standards. 【Methods】 Samples determined included fresh plasma collected and fresh plasma separated manually. The FⅧ∶C and Fib content were determined by coagulation method. The exon6 of ABO gene was amplified and sequenced to determine the genotype. 【Results】 The FⅧ∶C in fresh plasma collected was (147.421±45.773)%, and that in fresh plasma separated manually was (119.083±35.130)%, showing significant differences(P<0.05). The Fib content in fresh plasma collected was (2.252±0.381)g/L, and that in fresh plasma separated manually was (2.324±0.470)g/L, with no significant differences observed (P>0.05). The FⅧ∶C in non-O type (A, B, AB type) fresh plasma collected and fresh plasma separated manually were (167.048±40.862)% and (129.251±33.503)%, respectively, significantly higher than that in O type fresh plasma collected and fresh plasma separated manually as(121.386±38.632)% and (91.589±22.328)%, respectively. The Fib contents in non-O type fresh plasma collected and fresh plasma separated manually were (2.242±0.385)g/L and (2.329±0.472)g/L, respectively. The Fib contents in O type fresh plasma collected and fresh plasma separated manually were (2.287±0.370)g/L and (2.307±0.462)g/L, respectively, and no significant difference was noticed (P>0.05). 【Conclusion】 There was no significant correlation between Fib content and ABO blood group, while FⅧ∶C was significantly correlated with ABO blood group. In the preparation and quality control of FⅧ related blood products, the effect of ABO blood group on the FⅧ∶C should be considered, and the quality standard of FⅧ in plasma products should be established based on the ABO blood group.
