Effects of massive blood transfusion on inflammatory factors, islet B cell function, MODS incidence and mortality in patients with severe traumatic hemorrhage

Jingmei Zhang; Cunmin Feng; Yiming Zhang; Jinxia Zhao; Yun Xue; Xiuting Zhang; Shuai Wang; Zhanke Wang

Return

Effects of massive blood transfusion on inflammatory factors, islet B cell function, MODS incidence and mortality in patients with severe traumatic hemorrhage

VernacularTitle:大量输血对严重创伤失血患者炎症因子与胰岛B细胞功能及MODS发生率和病死率的影响
Author: Jingmei ZHANG ¹ ; Cunmin FENG ¹ ; Yiming ZHANG ² ; Jinxia ZHAO ¹ ; Yun XUE ¹ ; Xiuting ZHANG ¹ ; Shuai WANG ³ ; Zhanke WANG ²
Author Information

1. The Third Hospital of Xingtai, Xingtai 054000, China
2. The 908 Hospital of the Joint Service Support Force of the Chinese People′s Liberation Army
3. The General Hospital of Jizhong Energy Xingtai Mining Group Co., Ltd.
Publication Type:Journal Article
Keywords: massive blood transfusion; traumatic hemorrhage; multiple organ dysfunction syndrome(MODS); inflammatory factors; islet B cell; dysfunction
From: Chinese Journal of Blood Transfusion 2021;34(2):107-110
CountryChina
Language:Chinese
Abstract: 【Objective】 To explore the effect of massive blood transfusion on inflammatory factors, islet B cell function, incidence and mortality of multiple organ dysfunction syndrome (MODS) in patients with severe traumatic hemorrhage. 【Methods】 214 traumatic hemorrhage patients who received blood transfusion and were hospitalized in the Third People′s Hospital of Xingtai from January 2015 to June 2019 were enrolled and divided into the routine blood transfusion group (n=118) and massive blood transfusion group (n=96) according to the amount and method of blood transfusion. The changes of the inflammatory factors such as TNF α and IL-6, the functional indexes of Islet B cells such as HOMA-B and Δ INS30 / Δ GLU30, and the incidence and mortality of MODS in two groups 3 d after blood transfusion were observed. 【Results】 The level of TNF α(ng/L), IL-6(ng/L), HOMA-B and Δ INS30 / Δ GLU30 were (64.21±8.41) vs (30.75±5.26), (216.52±17.99) vs (152.45±16.26) (58.55±10.23) vs (103.47±17.48) and (2.95±0.69) vs (5.87±1.30) in the massive transfusion group and routine transfusion group, respectively (P<0.01). The incidence of MODS was 63.54%(61/96) vs 40.07%(52/118)(P<0.01) while the mortality of MODS was 46.88%(40/118) vs 33.90% (P>0.05). 【Conclusion】 The massive blood transfusion could increase the incidence of MODS in patients with severe traumatic hemorrhage by promoting inflammatory reaction and dysfunction of islet B cells.