Follow up of hemolytic changes in newborns induced by high titer IgG anti-D
10.13303/j.cjbt.issn.1004-549x.2021.05.015
- VernacularTitle:高效价IgG类抗-D致新生儿体内溶血的追踪观察
- Author:
Ziqiang LIU
1
;
Jing YANG
1
;
Guang YANG
1
;
Xuelong CHEN
1
;
Hong YUAN
1
Author Information
1. Department of Blood Transfusion, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu 610075, China
- Publication Type:Journal Article
- Keywords:
Rh blood group;
anti-D;
hemolytic disease of the newborn
- From:
Chinese Journal of Blood Transfusion
2021;34(5):501-504
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To analyze the results of maternal anti-D measured prenatally and serological tests of the newborn postnatally, so as to provide a basis for perinatal prevention and treatment of hemolytic disease of the newborn(HDN) in Rh negative pregnant women. 【Methods】 Irregular antibodies screening, antibody identification and titer determination were carried out for pregnant women prenatally. Blood group typing and 3 HDN tests were performed for the infant suspected as HDN. One-month follow up, since the delivery of the infant, concerning the changes in antibody titers, hemoglobin and bilirubin of the infant were monitored. 【Results】 The anti-D titer increased to 512 since 28 weeks in the parturient, 1 024 at 30 weeks of gestation, and decreased to 512 at the time of delivery. The masking effect on RhD antigen was observed after the birth of the child, with a sustained decrease in hemoglobin and a sharp increase in total and indirect bilirubin after 24 h of birth, which peaked within 48 h and gradually decreased thereafter.The antibody titers gradually decreased after birth. 【Conclusion】 Close monitoring of the changes of irregular antibody titer in Rh negative parturients is helpful for the prevention and early treatment of HDN, and hemoglobin changes in the newborn should be monitored immediately after birth, as well as symptomatic treatment to reduce the involvement of affected children.
