IgA removal by plasma component Ⅱ solution: A comparative study of different filter membrane combinations
10.13303/j.cjbt.issn.1004-549x.2021.03.023
- VernacularTitle:不同过滤膜组合对降低血浆组分Ⅱ溶解液IgA效果的比较
- Author:
Jing CAO
1
;
Bei CHEN
1
;
Yijun LIU
1
;
Hao CHEN
1
;
Chengbin GE
1
;
Xuan YE
2
;
Jing XU
1
Author Information
1. Sinopharm Shanghai Plasma-derived Biotherapies Co., Ltd, Shanghai 200051, China
2. 3M China Co., Ltd.
- Publication Type:Journal Article
- Keywords:
filter membrane;
IgA;
component Ⅱ solution;
IVIG
- From:
Chinese Journal of Blood Transfusion
2021;34(3):287-289
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To compare the effect of different combinations of filter membranes on the removal of IgA by component Ⅱ solution. 【Methods】 The dissolved solution of component Ⅱ was filtered with different combinations of filter membranes, and the turbidity, IgA residue, molecular size distribution and purity were compared. 【Results】 After filtering through the combination of NA-16+ Millpore 0.5μ, NA-16+ EmphazeTMAEX HP, and ZetaPlus™ + Emphaze™AEX HP filter membranes, the turbidity of the filtrate decreased by 35.5%(22.4/63.1), 39.2%(24.8/63.3) and 59.8%(37.4/62.5), the IgA residue decreased by 5.8%(14.77/253.70), 20.0%(50.90/254.00) and 44.3%(112.13/253.33), respectively.Molecular size distribution was 99.60%, 99.85% and 100%, and the purity was 100%, 100% and 100%, respectively. 【Conclusion】 The combination of ZetaPlus™ + Emphaze™AEX HP filter membrane can not only effectively remove IgA in the dissolution solution of component Ⅱ with other quality indicators remaining high-level, which can be used in IVIG large-scale production process.
