The distribution characteristics of Rh phenotype and haplotype frequency in Qingdao: An analysis based on some patients and local blood donors
10.13303/j.cjbt.issn.1004-549x.2021.03.001
- VernacularTitle:青岛市部分患者与献血者人群Rh表型及单体型频率分布特征分析
- Author:
Bo SUN
1
;
Xiaoyuan SUN
1
;
Changfeng SHAO
1
;
Yan LIU
1
;
Zheng LIU
1
;
Yuanming YANG
1
;
Zuzhou HUANG
1
;
Changkai ZHANG
1
;
Haiyan WANG
1
Author Information
1. Department of Blood Transfusion, the Affiliated Hospital of Qingdao University, Qingdao 266000, China
- Publication Type:Journal Article
- Keywords:
Rh phenotype;
Rh haplotype;
irregular antibody;
patients;
blood donors;
northern Chinese population;
blood transfusion
- From:
Chinese Journal of Blood Transfusion
2021;34(3):205-207
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the distribution characteristics of Rh blood group antigen phenotypes, haplotypes and irregular antibodies between patients in our hospital and local blood donors, so as to ensure safe and effective blood transfusion and improve the rationality and scientificity of clinical blood transfusion. 【Methods】 A total of 113 326 blood samples, from hospitalized patients in our hospital and local blood donors from October 2015 to March 2020, were subjected to Rh antigen typing and irregular antibody detection. The frequency of Rh phenotypes, haplotypes, and irregular antibodies were retrospectively analyzed and calculated. Chi square test was used to compare the data among different population groups. Rh antigen typing and irregular antibody detection were completed using the automatic blood group analyzer. 【Results】 The prevalence of negative RhD was 0.36% (408/113 326). The most prevalent Rh phenotype was DCCee [40.69%(46 112/ 113 326)] followed by DCcEe [36.82%(41 727/ 113 326)]. Anti-E was the most common irregular antibody, accounting for [0.26%(295/ 113 326)], and DCe [62.51%(70 840/ 113 326)] was the most common haplotype. The most common Rh phenotypes and haplotypes in Caucasians in Germany, North Indian and North African were DCcee, DCCee and Dccee, while DCe, DCe and Dce, respectively. 【Conclusion】 The distribution characteristics of Rh phenotypes, haplotypes and irregular antibodies of patients in our hospital and local blood donors were in line with the distribution characteristics of the population in northern China. Corresponding plans concerning blood storage and collection, as well as the establishment of Rh blood type registry should be carried to effectively ensure the safety, rationality and accuracy of clinical blood transfusion.
