Levofloxacin-induced acute hemolytic anemia: A clinical case report
10.13303/j.cjbt.issn.1004-549x.2021.04.017
- VernacularTitle:左氧氟沙星诱导急性溶血性贫血的诊治
- Author:
Conghai TANG
1
;
Dayi LIN
2
;
Yixuan LIN
1
;
Xiaoming HU
1
;
Weiwei GAN
1
;
Min YUAN
1
Author Information
1. Department of Transfusion, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China
2. Department of Hematology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China
- Publication Type:Journal Article
- Keywords:
whole blood exchange;
therapeutic plasma exchange;
levofloxacin antibody;
hemolytic anemia
- From:
Chinese Journal of Blood Transfusion
2021;34(4):392-395
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To study the clinical characteristics and treatment of patients with acute hemolytic anemia crisis induced by levofloxacin. 【Methods】 The levofloxacin antibody was detected by the microcolumn gel method and scored by the Naranjo Adverse Drug Reaction Probability Scale(APS). Patients suffered from acute hemolysis anemia induced by levofloxacin was rescued by whole blood exchange(WBE) and therapeutic plasma exchange(TPE). 【Results】 The patient was diagnosed as acute hemolysis induced by levofloxacin as levofloxacin antibody was yielded, and 7 points scored by the Naranjo APS. After WBE and TPE treatment, the patient′s clinical symptoms and signs improved rapidly. Supplemented with immunoglobulin and hormone therapy, the patient was discharged on d 10 after treatment. 【Conclusion】 Levofloxacin can induce acute hemolytic anemia crisis, and WBE and TPR are effective rescue methods.
