Blood screening strategy for SARS-CoV-2 among low risk populations
- VernacularTitle:新型冠状病毒感染低风险人群的血液筛查策略初探
- Author:
Linfeng WU
1
;
Lilin WANG
1
;
Xuqun WU
1
;
Yu ZHAO
1
;
Heng LIU
1
;
Junpeng ZHAO
1
;
Ran LI
1
;
Dandan DU
1
;
Xiaoxuan XU
1
;
Jinfeng ZENG
1
Author Information
- Publication Type:Journal Article
- Keywords: SARS-CoV-2; nucleic acid testing; total antibody detection; blood screening strategy
- From: Chinese Journal of Blood Transfusion 2021;34(4):343-346
- CountryChina
- Language:Chinese
- Abstract: 【Objective】 To analyze the viability of 2 different blood screening strategies against SARS-CoV-2 in low risk populations, so as to provide references for the formulation of blood screening strategy. 【Methods】 Two screening strategies for antibodies against SARS-CoV-2 were adopted: 1) the total antibody were initially screened for all samples, and the antibody IgG and IgM were retested in those primary positive samples; 2) only antibody test of IgG and IgM for all samples. And SARS-CoV-2 nucleic acid was detected in parallel. Reactive samples was confirmed by neutralization test. The sensitivity, specificity and true positive rate of two strategies were calculated. 【Results】 None was positive for SARS-CoV-2 nucleic acid among 880 samples. Four truly positive samples were implicated in 9 (1.02%, 9/880) initially reactive samples in total antibody test; 3 in 26 (2.95%, 26/880) initially IgG or IgM reactive samples. 【Conclusion】 The first strategy is superior to the second strategy in the sensitivity and specificity, and is recommended for the detection of SARS-CoV-2 antibody in low risk populations.
