Interference of CD38 monoclonal antibody in blood compatibility testing and its countermeasures: A general consensus among experts
10.13303/j.cjbt.issn.1004-549x.2021.04.001
- VernacularTitle:CD38单克隆抗体对输血相容性检测干扰及其应对方案的专家共识
- Author:
Jianqing MI
1
;
Xiaohong CAI
;
Shaoyuan WANG
2
;
Lihua HU
3
;
Ting NIU
4
;
Deqing WANG
5
;
Chengcheng FU
6
;
Chunyan SUN
;
Dong XIANG
7
;
Wen GAO
8
;
Tianhong MIAO
9
;
Liye ZHONG
10
;
Baohua QIAN
11
;
Gang AN
12
;
Rong XIA
13
;
Rong GUI
14
;
Jing LIU
14
;
Xiaofeng TANG
15
;
Jue XIE
16
;
Jia GAN
17
;
Jiang WU
;
Danhui FU
;
Li QIN
;
Jian HOU
18
;
Xuefeng WANG
Author Information
1. Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200000, China
2. Union Hospital Affiliated to Fujian Medical University
3. Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
4. West China Hospital, Sichuan University
5. Department of Blood Transfusion Medicine, First Medical Center, General Hospital of Chinese PLA
6. Department of Hematology, the First Affiliated Hospital of Suzhou University
7. Shanghai Blood Center Blood Group Reference Laboratory
8. Department of Hematology, Beijing Chaoyang Hospital
9. Institute of Hematology, Beijing Red Cross Blood Center
10. Department of Hematology, Guangdong Provincial People's Hospital
11. Department of Blood Transfusion, First Affiliated Hospital of Naval Medical University
12. Department of Hematology, Hematology Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
13. Department of Blood Transfusion, Huashan Hospital, Fudan University
14. Third Xiangya Hospital, Central South University
15. Department of Blood Transfusion, Second Affiliated Hospital of Naval Medical University
16. Department of Blood Transfusion, the First Affiliated Hospital of Medical College of Zhejiang University
17. Department of Blood Transfusion, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
18. Renji Hospital Affiliated to Medical College of Shanghai Jiaotong University
- Publication Type:Journal Article
- Keywords:
CD38 monoclonal antibody;
polybrene;
2-mercaptoethanol;
dithiothreitol;
blood compatibility testing
- From:
Chinese Journal of Blood Transfusion
2021;34(4):327-334
- CountryChina
- Language:Chinese
-
Abstract:
With continuous discovery of tumor immune targets and continuous changes in antibody research and development technology, antibody drugs are becoming more and more widely used in clinical practice. However, some targets are not only expressed on tumor cells, but also on red blood cells. Therefore, the clinical application of antibodies against the corresponding targets may interfere with the detection of blood transfusion compatibility, resulting in difficulty in blood matching or delay of blood transfusion. This consensus summarizes the current solutions for the interference of CD38 monoclonal antibody (CD38 mAb) in transfusion compatibility testing. After analyzing the advantages and disadvantages of different methods, polybrene and sulfhydryl reducing agents [dithiothreitol (DTT) or 2-mercaptoethanol (2-Me)], as a solution for CD38 mAb interference in blood compatibility testing, are recommended for Chinese patients, so as to eliminate blood transfusion interference produce by CD38 mAb and further provide a pre-transfusion workflow for clinicians and technicians in Department of Blood Transfusion.
