Research progress of red blood cells cultured in vitro

VernacularTitle:体外培养红细胞的研究进展
Author: Hangya LINGHU ¹ ; Daming GOU ¹
Author Information

1. Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China
Publication Type:Journal Article
Keywords: erythrocytes cultured in vitro: pathway; hematopoietic stem cell; bioreactor; transfusion
From: Chinese Journal of Blood Transfusion 2021;34(6):669-672
CountryChina
Language:Chinese
Abstract: Red blood cells (RBCs) are one of the most needed blood products in clinical blood transfusion treatment. At present, RBCs are mainly provided by blood donors, and the contradiction between supply and demand is extremely prominent. Customizable RBCs cultured in vitro bring dawn to solve this contradiction. RBCs can be differentiated and cultured from human induced pluripotent stem cells, immortalized adult erythroid progenitor cells, embryonic stem cells (ESCs), hematopoietic stem cells or the mononuclear cells extracted from umbilical cord blood and peripheral blood. Each method, with its own advantages and drawbacks, are still in the stage of laboratory research. However, according to the current progress, it is not far from clinical application. This paper summarizes the progress in this field.