Assessing Hemocompatibility of Transfusion Sets for Single Use
10.13303/j.cjbt.issn.1004-549x.2021.06.009
- VernacularTitle:一次性使用输血器的血液相容性研究
- Author:
Ye CAO
1
;
Chunxia QIAO
2
;
Jiaxin LIU
1
;
Xuejun ZHANG
1
;
Zeng HE
1
;
Yan WANG
2
;
Rui ZHONG
1
;
Hong WANG
1
Author Information
1. Chinese Academy of Medical Sciences& Peking Union Medical College, Institute of Blood Transfusion, Sichuan, Chengdu 610052, China
2. Shandong Quality Inspection Center For Medical Devices
- Publication Type:Journal Article
- Keywords:
single-use transfusion set;
blood compatibility;
blood component loss;
blood component damage/activation
- From:
Chinese Journal of Blood Transfusion
2021;34(6):603-606
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the blood compatibility of transfusion sets for single use, the loss, damage and activation of blood components after passage through the transfusion sets. 【Methods】 Transfusion sets (sample A and B) were assessed by comparing samples of blood component taken prior to and after passage through. The following makers of damage/activation were evaluated: Red blood cells (RBCs)-supernatant free hemoglobin (FHb) and potassium(K+ ) amount; platelet concentrates (PCs)-pH, hypotonic shock response (HSR), supernatant lactate dehydrogenase(LDH), CD62P; fresh frozen plasma(FFP) – prothrombin fragments 1 and 2 (F1+ 2), fibrinopeptide A (FPA), coagulation factor Ⅻa (FⅫa), Thrombin-antithrombin complex (TAT). 【Results】 After passing through two types of transfusion sets, the loss of RBCs, PCs and FFP were less than 5%. There is no statistic difference for the change of FHb and K+ of RBCs(P>0.05). There were no statistics for pH, LDH(U/L) and CD62P(%) after platelet concentrates passing through both transfusion sets. There was no statistics for the HSR after passing through the sample A, while there was a small but statistically significant increase in the HSR of sample B (37.17±6.49 vs 40.75±6.24, P<0.05). After FFP passing through the transfusion giving sets, there were no statistical difference for F1+ 2, FPA, FⅫa and TAT (P>0.05). 【Conclusion】 Two types of transfusion sets caused negligible effects on RBCs, platelet concentrates and FFP.
