Effect of red blood cell parameters and blood donation interval on ferritin level in apheresis platelet donors with ferritin deficiency
10.13303/j.cjbt.issn.1004-549x.2021.06.006
- VernacularTitle:铁蛋白缺乏的单采血小板捐献者红细胞参数变化以及献血间隔对体内铁蛋白水平的影响
- Author:
Jing WANG
1
;
Chunlian SUN
1
Author Information
1. Binzhou Blood Center, Binzhou 256600, China
- Publication Type:Journal Article
- Keywords:
ferritin deficiency;
apheresis platelet donor;
red blood cell parameters;
blood donation interval
- From:
Chinese Journal of Blood Transfusion
2021;34(6):590-594
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To study the effect of changes in red blood cell parameters and blood donation interval on ferritin level in platelet donors with ferritin deficiency, so as to provide experimental evidence for formulating targeted blood donor care strategies. 【Methods】 100 regular male platelet apheresis donors in April 2020 were selected to test the ferritin and red blood cell parameters. Blood donors were classified according to the annual blood donation numbers: 3~10, 11~15, and 16~24, and the difference of iron deficiency rate among groups was analyzed. They also were classified according to the detection value of ferritin: iron deficiency donors versus SF normal donors, and the changes of Hb, MCV, MCH and MCHC values of them were compared. The iron deficiency donors were stratified by donation time: January to March 2019, April to June 2019, July to September 2019, October to December 2019 and January to April 2020, so as to compare the changes of Hb, MCV and MCH values among each group. The iron deficiency donors, continued the donation afterwards, were divided into interval-extended donors (minimum donation interval of 30 days) and normal ones (minimum donation interval of 14 days), and blood donation from May to December 2020 was intervened and observed. In December 2020, serum ferritin was tested again for iron deficiency donors to analyze the changes in SF between two groups. 【Results】 The incidence of iron deficiency in three groups with different donation frequency was 7.5%, 22.5% and 40.0%, respectively(P<0.05). The Hb(g/L) (144.15±9.37 vs 151.72±8.81), MCV(fl)( 87.21±4.02 vs 89.38±2.96), MCH(pg)(29.91±2.13 vs 31.01± 1.25), and MCHC (g/L)(345.85±9.08 vs 346.48±9.18) of iron deficiency donors were significantly lower than those of SF normal ones(P<0.05). The paired-comparison of Hb of iron deficiency donors was not statistically different by donation periods, except for January-April 2020 versus January-March 2019(P<0.05). MCV mean values were statistically different by donation periods, especially January-April 2020 versus January-March/April-June/July-September 2019 and October-December 2019 versus January-March 2019(P<0.05). MCH mean values were statistically different by donation periods, especially January-April 2020 versus January-March/ April-June and October-December 2019 versus January-March 2019(P<0.05). The pre-collection distribution of Hb, MCV, and MCH in iron deficiency donors and SF normal donors during 2019 and 2020 were 0.030±0.008 vs 0.025±0.004, 0.011±0.006 vs 0.007±0.002, and 0.019±0.008 vs 0.013±0.005, respectively (P<0.05). .The Hb, MCV, and MCH values of high-frequency blood donors with Hb less than 130g/L decreased significantly. The original SF (μg/L) of iron-deficiency donors without extended interval was 13.89±4.66, and the current 12.27±5.17(P>0.05), and original 13.89±4.66 vs current 35.92±5.20 in the extended ones(P<0.05). 【Conclusion】 The incidence of iron deficiency in apheresis platelet donors increased as blood donation frequency elevated. The Hb, MCV, MCH and MCHC value of iron deficiency donors decreased while the dispersion of pre-collection Hb, MCV and MCH decreased. MCV and MCH are superior to Hb in early-reflection of metabolism status of red blood cell. It is recommended that iron deficiency donors with Hb less than 130 g/L should reduce the frequency of donation. Extending the donation interval can increase the SF level of iron deficiency donors.Dynamic monitoring of ferritin and related red blood cell parameters should be carried out by blood banks to customize the donation interval.
