Epidemiological characteristics of occult hepatitis C virus and safety of blood transfusion
10.13303/j.cjbt.issn.1004-549x.2021.07.032
- VernacularTitle:隐匿性丙型肝炎病毒流行病学特点与输血安全
- Author:
Huixia ZHAO
1
;
Shufang SUN
1
;
Tongxian WANG
1
Author Information
1. Qingdao Blood Center, Qingdao 266071, China
- Publication Type:Journal Article
- Keywords:
occult hepatitis C infection;
blood transfusion;
hepatitis C virus;
epidemiology;
peripheral blood mononuclear cell;
anti-HCV;
HCV RNA
- From:
Chinese Journal of Blood Transfusion
2021;34(7):793-796
- CountryChina
- Language:Chinese
-
Abstract:
Occult hepatitis C infection (OCI) is defined as HCV RNA not detected in serum or plasma but in hepatocytes and peripheral blood mononuclear cells (PBMCs). OCI exists in general population and voluntary blood donors, and its infectivity and risk of transmission by transfusion has been confirmed. HCV RNA in PBMCs could not be detected in plasma or serum by blood screening in transfusion services, neither by enzyme-linked immunosorbent assay nor by nucleic acid amplification testing. OCI has become a potential threat to transfusion safety, therefore effective detection technologies and transmission blocking strategies need to be further developed.
