Crossmatch incompatibility in infants caused by intravenous immunoglobulin-produced IgG antibody: Six cases
10.13303/j.cjbt.issn.1004-549x.2021.07.027
- VernacularTitle:静脉丙种球蛋白致婴幼儿产生IgG类抗体及交叉配血不合6例
- Author:
Xiaohong JIN
1
;
Kexuan QU
1
;
Rui CHEN
1
;
Rong ZHOU
1
;
Xin WANG
1
;
Mengxing LV
1
Author Information
1. Department of Blood Transfusion, Kunming Children′s Hospital, Kunming 650228, China
- Publication Type:Journal Article
- Keywords:
intravenous immunoglobulin;
hemolytic disease of the newborn;
IgG anti-A;
crossmatch
- From:
Chinese Journal of Blood Transfusion
2021;34(7):776-778
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To analyze the effect of intravenous immunoglobulin(IVIG)-produced IgG antibody on the crossmatch incompatibility of neonates. 【Methods】 Blood type grouping, antibody screening, crossmatch, direct anti-globulin test, elution test, indirect antiglobulin test, and IVIG titer determination were conducted by microcolumn gel method. 【Results】 IgG anti-A were detected out in the elution test and free antibody test of 6 infants, and the titer of IgG anti-A contained in IVIG was 256, which led to the crossmatch incompatibility between infants and donors with the same type. 【Conclusion】 The hemolysis and crossmatch incompatibility in newborns, born to ABO-compatible mothers, may occur due to the IVIG-induced IgG antibodies. The O-type washed red blood cells should be selected for transfusion.
