Centrifugal plasma separation combined with plasma adsorption in the treatment of hypertriglyceridemia: A clinical observation of 42 cases
10.13303/j.cjbt.issn.1004-549x.2021.07.005
- VernacularTitle:离心式血浆分离联合血浆吸附法降低高血脂的效果分析
- Author:
Yan BAI
1
;
Jianjun WU
2
;
Jingfang YANG
3
;
Shuming ZHAO
2
Author Information
1. Department of Blood Transfusion, Jingdong Yumei Nephropathy Hospital of Integrated Traditional Chinese and Western Medicine, Sanhe 065201, China
2. Department of Blood Transfusion, GuiQian International General Hospital
3. Department of Blood Transfusion, the Second Affiliated Hospital of Hebei Medical University
- Publication Type:Journal Article
- Keywords:
hypertriglyceridemia;
plasma adsorption;
centrifugal plasma separation;
adverse reactions
- From:
Chinese Journal of Blood Transfusion
2021;34(7):691-694
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the clinical efficacy and safety of centrifugal plasma separation combined with plasma adsorption in the treatment of hypertriglyceridemia. 【Methods】 The data of 42 patients with hypertriglyceridemia from February 2019 to October 2020 were retrospectively collected and analyzed. The patients were treated with plasma component exchange by centrifugal plasma separation combined with plasma adsorption (PA) lipid-lowering therapy. The plasma was separated by an automatic blood cell separator, and was then adsorbed by membrane plasma component absorber. Conditions for plasma component exchange were sodium citrate as anticoagulant, the whole blood flow rate at (30~80) mL/min, the plasma circulation volume 2 500 mL, the treatment time 2 h, and the discarded plasma 200 mL. The treatment was performed once every two weeks, twice in total, and the efficacy was evaluated 6 weeks later. The changes of serum total protein (TP), blood lipid indexes and hemorheology indexes before and after treatment were observed, and the adverse reactions during treatment were recorded. 【Results】 The effective rate of 42 patients after treatment was 95.24%. The values of TP, TC, TG and LDL-C decreased significantly (82.53±6.37 vs 74.26±5.91, 7.46±1.83 vs 3.88±1.06, 5.91±2.16 vs 2.20±1.13, 4.23±1.02 vs 3.17±0.85) while HDL-C increased significantly(0.92±0.15 vs 1.23±0.26) after the treatment (P<0.05). After the treatment, the levels of whole blood high-cut viscosity, whole blood low-cut viscosity, plasma viscosity, hematocrit and fibrinogen decreased significantly (7.53±1.21 vs 5.16±0.88, 18.27±3.15 vs 12.04±2.32, 2.46±0.37 vs 1.68±0.29, 52.24±5.31 vs 32.53±4.42, 4.28±0.76 vs 3.14±0.45)(P<0.05). The incidence of adverse reactions was 14.3%, and no serious adverse reactions were observed. 【Conclusion】 The centrifugal plasma separation combined with plasma adsorption in the treatment of hypertriglyceridemia is safe and effective.
