Research progress of clinical application of human fibrinogen
10.13303/j.cjbt.issn.1004-549x.2021.08.036
- VernacularTitle:人纤维蛋白原的临床应用研究进展
- Author:
Ge LIU
1
;
Qiang CHEN
2
;
Zhongjun CHU
2
;
Hengqu WU
Author Information
1. School of Life Sciences, East China Normal University, Shanghai 200221, China
2. Shanghai RAAS Blood Products Co Ltd.
- Publication Type:Journal Article
- Keywords:
human fibrinogen;
preclinical research;
clinical application
- From:
Chinese Journal of Blood Transfusion
2021;34(8):935-938
- CountryChina
- Language:Chinese
-
Abstract:
In bleeding events caused by various reasons, coagulation dysfunction due to massive consumption or loss of coagulation factors is often life-threatening. In recent years, medical evidence of using human fibrinogen concentrate to prevent or treat bleeding has emerged, providing more options for clinical treatment of bleeding. In this paper, the stability, pharmacokinetics and safety of human fibrinogen, as well as the latest advances in its clinical application in obstetrics, cardiac surgery and traumatic massive hemorrhage were summarized, and new reasonable suggestions for clinical application of human fibrinogen were also put forward.
