Advances of pathogen inactivation technology in blood components and quality evaluation

VernacularTitle:病原体灭活技术在血液成分中的应用进展及质量评价
Author: Xiaoyu GUAN ^{1
,

2
,

3} ; Qiuhong MO ^{1
,

2
,

4} ; Ling LI ^{1
,

2} ; Zhong LIU ^{1
,

2}
Author Information

1. Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College, Chengdu 610052, China
2. Key Laboratory of Transfusion Adverse Reactions, CAMS
3. Anhui Medical University
4. Nanning Central Blood Station
Publication Type:Journal Article
Keywords: pathogen inactivation technology; blood composition; quality evaluation
From: Chinese Journal of Blood Transfusion 2021;34(8):930-935
CountryChina
Language:Chinese
Abstract: Through the screening of blood donors, detection of pathogen antigen and antibody, full coverage of nucleic acid detection, the risk of infectious blood transfusion has been reduced to a very low level. Especially, pathogen inactivation technology (PRT) has played an irreplaceable role in ensuring blood safety. The best way to inactivate pathogens is not only to effectively remove the target pathogens in the blood, but also to maintain the activity of active ingredients in the blood to the maximum extent, and it doesn′t affect the effect of blood therapy. In this paper, the development of pathogen inactivation technology is summarized, and the influence of pathogen inactivation treatment on the quality of blood components is discussed. It provides references for improving or developing new processing technology.