Potential of modulating fibrinolytic activity in intervention of transfusion-related acute lung injury
10.13303/j.cjbt.issn.1004-549x.2021.08.033
- VernacularTitle:调节纤维蛋白溶解活性干预输血相关急性肺损伤的潜能探讨
- Author:
Yunhong YU
1
,
2
;
Peng JIANG
1
;
Pan SUN
1
;
Na SU
1
;
Xin YUAN
1
;
Fangzhao LIN
1
Author Information
1. Institute of Blood Transfusion, Chinese Academy of Medical Science & Peking Union Medical College, Chengdu 610052, China
2. The Third people′s hospital of Chengdu
- Publication Type:Journal Article
- Keywords:
transfusion-related acute lung injury(TRALI);
acute lung injury (ALI);
fibrinolytic activity;
fibrin deposition;
intervene
- From:
Chinese Journal of Blood Transfusion
2021;34(8):922-925
- CountryChina
- Language:Chinese
-
Abstract:
Transfusion-related acute lung injury (TRALI), with clinical manifestation, diagnosis and pathological mechanism consistent with acute lung injury(ALI), belongs to a sub-category of ALI. Excessive deposition of fibrin in lung is one of the characteristic of ALI, and reversing fibrin formation is of great significance to intervene ALI. The decrease of fibrinolytic activity is one of the important causes of excessive deposition of fibrin in lung, and also the important pathological feature of TRALI. This article discusses the potential of modulating fibrinolytic activity to intervene TRALI from the perspective of regulating the effectiveness of fibrinolytic activity to intervene ALI.
