Clinical application of washed red blood cells in perioperative patients with liver cancer
10.13303/j.cjbt.issn.1004-549x.2021.08.014
- VernacularTitle:洗涤红细胞在围手术期肝癌患者中的临床应用研究
- Author:
Xuemei WANG
1
;
Hua WANG
2
;
Guanzhong LIANG
3
;
Xinli LI
1
;
Jicheng LIAO
1
;
Weidong YIN
1
;
Shuya YANG
1
Author Information
1. The Sixth People′s Hospital Of Chengdu, Chengdu 610051, China
2. The First Affiliated Hospital of Southwest Medical University
3. Cancer Hospital of Chongqing
- Publication Type:Journal Article
- Keywords:
liver cancer;
blood transfusion;
recurrence;
metastasis;
adverse reaction
- From:
Chinese Journal of Blood Transfusion
2021;34(8):858-860
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To estimate the application value of washed red blood cells (RBC) in perioperative patients with liver cancer. 【Methods】 86 perioperative patients with liver cancer who met the inclusion/exclusion criteria were divided into observation group (n=42) and control group (n=44). In the observation group, 22 patients were transfused with RBC and 20 with washed RBC. Patients without RBC transfusion worked as the controls. The name of disease, tumor stage, tumor size, Hb before and after blood transfusion, transfusion volume and blood components, adverse reaction to blood transfusion, operation time and blood loss during surgery, systemic infection, tumor recurrence and metastasis, and survival time were recorded. Blood transfusion efficacy, survival time, adverse reaction to blood transfusion, tumor recurrence and metastasis among these groups were compared. 【Results】 Among the non-transfusion group, washed RBC group and RBC group, the Hb(g/L)were 93.9±16.5 vs 80.4±24.5 vs 74.7±26.1, operative time (h) 2.8±0.7 vs 4.3±1.6 vs 3.9±2.0, operative blood loss(mL) 291.0±0.3 vs 388.0±165.8 vs 466.3±198.4 respectively before blood transfusion (all P<0.05). There were no significant differences in the efficacy of blood transfusion and survival time among the three groups (P>0.05). There were significant differences in tumor metastasis (50% vs 43%) and recurrence (50% vs 43.1%) between blood transfusion group and non-blood transfusion group (P<0.05). There was no difference in tumor metastasis (50% vs 48%) and recurrence (50% vs 49%) between the washed RBC group and RBC group (P>0.05). The nosocomial infection rate in washed RBC group (36%) was significantly lower that that in RBC group (88.6%) and non-transfusion group (50%) (P<0.05). 【Conclusion】 Blood transfusion caused by hypoxia may increase tumor metastasis and recurrence in perioperative patients with liver cancer. Transfusion of washed RBC can achieve the curative effect and reduce adverse reactions to blood transfusion, but has no significant impact on the survival time.
