Correlation of DAT-positive hemolytic anemia with gender, age and ABO serological indicators
10.13303/j.cjbt.issn.1004-549x.2021.08.011
- VernacularTitle:DAT阳性溶血性贫血与性别、年龄及ABO血清学指标相关性
- Author:
Junhui QUAN
1
;
Xiang SHAO
2
;
Minggang ZHANG
1
Author Information
1. Department of Blood Transfusion, Second Affiliated Hospital of Xi′an Jiaotong University, Xi′an 710004, China
2. Spleen and Stomach First Ward, Shaanxi Provincial Hospital of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
HA;
gender;
age;
ABO serological indicators;
correlation
- From:
Chinese Journal of Blood Transfusion
2021;34(8):847-850
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the correlation of DAT-positive hemolytic anemia(HA) with gender, age, and ABO serological indicators (anti-A, anti-B, anti-AB, anti-D; Ac, Bc, Oc), so as to provide references for clinical diagnosis. 【Methods】 2 832 HA patients who had underwent DAT tests in the Second Affiliated Hospital of Xi′an Jiaotong University in recent years were divided into the positive-DAT patients ( n=382 )and negative-DAT patients (n=2 450 ) according to the testing results. The correlation between the positive-DAT patients and the sex, age and ABO serological indicators was analyzed using SPSS 25.0 statistical software. 【Results】 DAT-positive HA risk in women were significantly higher than men (OR=1.712, CI95%= [1.365, 2.147], P<0.01), and it differed significantly by ages; it increased significantly with the presence of positive anti-A, negative Ac (OR=1.429, CI95%= [1.150, 1.775] ; P<0.01), and positive Oc(OR=21.369, CI95%= [13.813, 33.057] ; P<0.01). Men aged 31~40 were prone to develop mixed type(OR=19.304, CI95%= [2.208, 168.751] ; P<0.01), women aged 41~50 were prone to cold antibody(OR=3.981, CI95%= [1.545, 10.259] ; P<0.01); anti-AB positive patients were prone to mixed type (OR=1.852, CI95%= [1.027, 3.339] ; P<0.05), Oc positive was prone to warm antibody(OR=4.018, CI95%= [1.386, 1.646], P<0.01). 【Conclusion】 DAT-positive HA is significantly correlated with gender and age, and is positively correlated with anti-A, Oc positive and Ac negative.
