Elimination of autoantibodies interference with blood group identification and its treatment effect

Jun Deng; Rong Huang; Fengxia Liu; Yixin XU; Liang Liu; Sijia Deng; Qinyi Zhang; Qian Zhang; Xiaotao MO; Hui Yang; Chunyan LI; Rong Gui

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Elimination of autoantibodies interference with blood group identification and its treatment effect

VernacularTitle:自身抗体影响血型鉴定的处理方法及效果
Author: Jun DENG ¹ ; Rong HUANG ² ; Fengxia LIU ² ; Yixin XU ³ ; Liang LIU ¹ ; Sijia DENG ¹ ; Qinyi ZHANG ¹ ; Qian ZHANG ¹ ; Xiaotao MO ¹ ; Hui YANG ³ ; Chunyan LI ³ ; Rong GUI ²
Author Information

1. Department of Clinical Laboratory, Changsha Central Hospital, Changsha 410004, China
2. Department of Blood Transfusion, the Third Xiangya Hospital of Central South University
3. Department of Blood Transfusion, Changsha Central Hospital
Publication Type:Journal Article
Keywords: autoantibodies; blood group identification; special serological test
From: Chinese Journal of Blood Transfusion 2021;34(8):818-820
CountryChina
Language:Chinese
Abstract: 【Objective】 To summarize a rapid and effective method to eliminate autoantibodies interference with blood group identification and evaluate its treatment effect. 【Methods】 Blood samples with suspicious results in initial blood group identification were collected, and those caused by autoantibodies were chosen, and their red blood cells were washed, dispersed or treated with sulfhydryl reagent. After allogeneic or autologous absorption of plasma, blood groups of those patients were re-detected to evaluate the effectiveness of the above method. 【Results】 Among 39 patients presenting suspicious ABO blood group, 9 were interfered by autoantibodies. After appropriate treatment, the ABO/RhD blood group of those patients could be identified. 【Conclusion】 Autoantibodies could interfere the identification of ABO/RhD blood group, and the efficiency and accuracy of blood group identification could be improved by analyzing the test results and selecting appropriate treatment methods.