Function of platelet-derived extracellular vesicles in adverse reactions to blood transfusion
10.13303/j.cjbt.issn.1004-549x.2021.09.030
- VernacularTitle:血小板来源的细胞外囊泡在输血不良反应中的作用
- Author:
Ziyue MI
1
;
Zhong LIU
1
;
Li TIAN
1
Author Information
1. Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu 610052, China
- Publication Type:Journal Article
- Keywords:
platelet;
extracellular vesicles;
exosomes;
transfusion-related acute lung injury (TRALI);
inflammation;
coagulation
- From:
Chinese Journal of Blood Transfusion
2021;34(9):1050-1054
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have shown that a series of structural and functional changes would occur during the process of platelet collection, storage and transfusion. The storage of platelets would induce the production of extracellular vesicles. During the process of platelet transfusion, extracellular vesicles play a critical role by carrying diverse substances under various pathophysiological conditions, which causes adverse reactions to blood transfusion. Ceramide and soluble CD40L (sCD40L) carried by platelet-derived extracellular vesicles may lead to transfusion-related acute lung injury (TRALI). Extracellular vesicles containing mtDNA are considered as damage-associated molecular patterns (DAMPs), which can mediate local and systemic inflammation and promote inflammation through interactions with leukocytes and monocytes. Platelet derived extracellular vesicles contain lots of procoagulant substances, which are considered as prethrombotic substances. The RNA of varying species or content carried by vesicles during the process of platelet storage may also related to the occurrence of adverse reactions to blood transfusion.
