Advances in the anti-ageing effects of GDF11 in blood
10.13303/j.cjbt.issn.1004-549x.2021.09.028
- VernacularTitle:血液中的生长分化因子11在抗衰老领域的研究进展
- Author:
Zongkui WANG
1
,
2
;
Rong ZHANG
1
,
2
;
Changqing LI
1
,
2
Author Information
1. Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College, Chengdu 610052, China
2. International Science and Technology Cooperation Base of Sichuan Blood Safety and Blood Substitute
- Publication Type:Journal Article
- Keywords:
growth differentiation factor 11;
anti-ageing;
cardiac hypertrophy;
skeletal muscle;
cognitive decline
- From:
Chinese Journal of Blood Transfusion
2021;34(9):1041-1046
- CountryChina
- Language:Chinese
-
Abstract:
Growth differentiation factor 11 (GDF11), a member of the transforming growth factor β superfamily, is widely expressed in multiple species such as human, mouse, rat, horse and sheep. Moreover, GDF11 is implicated in diverse biological functions and plays an important role in regulating anterior/posterior patterning, skeletal muscle regeneration, bone formation, vascular remodeling and neurogenesis. Recent studies have revealed that GDF11 in blood reverses age-related cardiac hypertrophy, skeletal muscle dysfunction and age-related cognitive decline, suggesting the potential value of GDF11 on anti-ageing. However, some other studies questioned the effects of GDF11 on anti-ageing. Herein, we highlighted structural characteristics of GDF11, advances in effects of GDF11 on anti-ageing, and the controversies of GDF11, to provide new insights for future studies on anti-ageing.
