Discussion on the reference range of thromboelastogram in 916 healthy adults in Shenzhen area
10.13303/j.cjbt.issn.1004-549x.2022.03.018
- VernacularTitle:深圳地区916例健康体检者血栓弹力图参考范围的探讨
- Author:
Weicheng LI
1
;
Kunlun WU
1
;
Siqi CAI
1
;
Guodu ZHU
1
;
Yubao ZHONG
1
;
Yunjing XU
1
;
Nansheng CAI
1
;
Lili WU
1
;
Zhenglin WU
1
Author Information
1. Department of Blood Transfusion, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518000, China
- Publication Type:Journal Article
- Keywords:
thromboelastogram(TEG);
reference range;
healthy adults in Shenzhen
- From:
Chinese Journal of Blood Transfusion
2022;35(3):304-307
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To determine the reference range of thromboelastogram(TEG) and establish a TEG feature for local population by measuring TEG parameters in healthy adults in Shenzhen comparing the difference between gender and age, and analyzing the reference data provided by reagent manufacturer. 【Methods】 A total of 916 healthy adults, aged between 19 to 59, who did their regular health checks in our hospital from September 2020 to August 2021 were selected. The TEG(from Lepu Medical Technology Co., Ltd.) was performed, and the clot reaction time(R), clot formation time(K), coagulation angle(α-Angle), maximum amplitude(MA), coagulation index(CI), fibrinolysis index LY30 and the estimated percent lysis (EPL) were analyzed. 【Results】 The reference ranges of TEG parameters, including R, K, α-Angle, MA, CI, LY30 and EPL, of 916 healthy adults from Shenzhen were 3.25~8.19 min, 0.66~3.18min, 47.70~76.56deg, 50.05~72.91mm, -4.3~3.4, 0~2.2% and 0~3%, respectively. The value of α-Angle, CI, K, LY30, MA and R didn’t all meet the given range provided by the manufacturer; some were exceeding and some inferior to. A total of 227 out of 916 individuals presented abnormal results, relative to the references, in at least one parameter, and 78 were diagnosed of abnormal coagulation based on the given reference range, with a specificity of 75.2%. 【Conclusion】 The reference range of TEG parameters of Shenzhen locals is significantly different from that provided by manufacturers. And it is imperative for local TEG laboratories to establish their own reference ranges according to age and gender groups based on local population characteristics.
