Classification management of HIV reactive blood donors based on test results
10.13303/j.cjbt.issn.1004-549x.2022.03.016
- VernacularTitle:基于HIV检测结果对反应性献血者分类管理的探讨
- Author:
Rui WANG
1
;
Ling LI
2
;
Zhengmin LIU
1
;
Jin GUO
1
;
Jinghui HU
1
;
Jing ZHANG
1
;
Hongwei GE
1
;
Zhong LIU
2
Author Information
1. Beijing Red Cross Blood Center, Beijing 100088, China
2. Institute of Blood Transfusion, Peking Union Medical College, Chinese Academy of Medical Sciences
- Publication Type:Journal Article
- Keywords:
human acquired immunodeficiency virus (HIV);
enzyme linked immunosorbent assay (ELISA);
nucleic acid detection (NAT);
blood donor
- From:
Chinese Journal of Blood Transfusion
2022;35(3):296-300
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the viability of classification management of HIV reactive blood donors based on test results in blood screening laboratory. 【Methods】 According to the HIV test results of blood donors (including twice ELISA and once NAT), the HIV reactive blood donors were divided into three groups. Group 1 was all-test reactive (both ELISA and NAT were reactive), group 2 serological reactive (only ELISA was reactive), and group 3 NAT reactive (only NAT was reactive). The HIV test results of 191 628 blood donors from May to December 2017 were analyzed. Samples with positive RIBA results and / or the repeated reactive NAT results were determined as HIV true positive. The yielding rates of HIV true positivity in each group were analyzed. Receiver operating characteristic curve (ROC curve) was used to elevate the S/CO limit under 99% specificity as the blood donor deferral limit for ELISA. 【Results】 A total of 180 HIV reactive samples were detected out of 191 628 blood donors, including 77 positive cases in group 1, 100 in group 2 and 3 in group 3. 1) The HIV reactive results were diverse. Among the 82 true positive blood donors, 4 were early HIV infection (3 HIV antibody+ antigen window period yield, 1 HIV antibody window period yield), 2 were suspected elite controllers, and 76 cases were both serology and NAT reactive. 2) The overall yielding rate of HIV was 47.67%, with group 1 (100%) = group 3 (100%) > group 2 (2.17%), showing statistically significant (P<0.01). 3) The blood donor deferral limit for ELISA1, ELISA2 was 5.40 and 9.69 (S/CO value), respectively, with the corresponding positive expective values of 98.73% and 91.14% (P>0.05). All true positive blood donors in group 1 and group 2 could be accurately screened by using the blood donor deferral limit for ELISA1 and ELISA2 simultaneously. 【Conclusion】 The composition of HIV results among blood donors is diverse and complex. It is necessary to continuously improve the awareness of HIV prevention and control. The classification of HIV reactive blood donors is conducive to conduct fine and scientific management. The blood donors in group 1 and group 3 should be permanently deferral, and the suspected HIV elite controllers in group 2 should be paid attention to and permanently deferral.
