Prevalence and risk factors of hepatitis B virus among voluntary blood donors, Guangzhou from 2011 to 2020
10.13303/j.cjbt.issn.1004-549x.2022.03.013
- VernacularTitle:近10年广州地区无偿献血者乙肝流行特征及危险因素分析
- Author:
Junmou XIE
1
;
Zhongping LI
1
;
Haojian LIANG
1
;
Boquan HUANG
1
;
Zhijian HUANG
1
;
Hao WANG
1
;
Yourong ZHENG
1
Author Information
1. Guangzhou Blood Center, Guangzhou Key Laboratory of Medical Sciences (Blood Safety), Guangzhou 510095, China
- Publication Type:Journal Article
- Keywords:
HBV;
hepatitis B vaccine;
voluntary blood donors;
epidemiologic characteristics;
risk factors
- From:
Chinese Journal of Blood Transfusion
2022;35(3):284-288
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To assess the trend of hepatitis B virus (HBV) prevalence and associated risk factors among voluntary blood donors in Guangzhou area from 2011 to 2020, and to explore the impact of hepatitis B vaccination in neonates on the risk of HBV infection. 【Methods】 Blood samples of 2 624 434 voluntary blood donors from 2011 to 2020 in Guangzhou were tested by HBV surface antigen (HBsAg) enzyme-linked immunosorbent assay (ELISA) reagents twice and nucleic acid test (NAT) reagent once. Samples reactive to ELISA twice, or ELISA once + NAT were considered as HBV infection. The gender, age, ethnicity and region of HBV infected blood donors were collected, and the incidence of HBV infection in blood donors born before and after 1992 (when HBV vaccination was conducted in neonates) was compared. The trend and risk factors of HBV infection in blood donors in Guangzhou from 2011 to 2020 were analyzed. 【Results】 An overall HBV prevalence of 0.75% was found in voluntary blood donors in Guangzhou area from 2010 to 2020, showing an overall downward trend(P<0.05). HBV prevalence was lower in blood donors born after 1992 (0.49 %, 4 825/98 5362) than prior to 1992 (P<0.05). HBV prevalence in male blood donors (0.89%, 15 049/1 695 062) was significantly higher than that in female blood donors (P<0.05). HBV prevalence in blood donors aged 18~25(0.52%, 6 337/1 219 282)was lower than that in other age groups (P<0.05). HBV prevalence was similar in donors resident in Guangdong and other provinces(P>0.05), but both were significantly higher than that in Hong Kong, Macao, Taiwan and foreign countries (P<0.05). HBV prevalence in Han nationality donors was significantly higher than the ethnic minority donors (P<0.05). Gender, age, ethnicity and birth vaccination are the main risk factors for HBV infection among blood donors. 【Conclusion】 The overall HBV prevalence among voluntary blood donors in Guangzhou area from 2011 to 2020 has shown a decreasing trend, and differences have been found in gender, age, region, ethnicity and birth vaccination, which is helpful to formulate targeted recruitment strategies, thus reducing the risk of transfusion transmitted HBV.
