Application of autologous platelet-rich plasma in the treatment of postoperative bone nonunion for long bone shaft fractures during and after operation
10.13303/j.cjbt.issn.1004-549x.2022.03.005
- VernacularTitle:术中及术后使用自体富血小板血浆治疗长骨干骨折后骨不连的应用
- Author:
Yubing XU
1
;
Guangya LIU
1
;
Xuqiong CHEN
2
;
Zhanhong ZHU
1
;
Mou ZHOU
1
;
Wei ZHANG
1
;
Guiqiu SHAN
1
Author Information
1. Department of Blood Transfusion, General Hospital of Southern Theater Command, Guangzhou 510010, China
2. Orthopedics Department, General Hospital of Southern Theater Command, Guangzhou 510010, China
- Publication Type:Journal Article
- Keywords:
platelet-rich plasma;
long bone shaft fracture;
bone nonunion;
autologous plasma
- From:
Chinese Journal of Blood Transfusion
2022;35(3):254-257
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the clinical effects of autologous platelet-rich plasma (PRP) in the treatment of postoperative bone nonunion for long bone shaft fractures during operation and after operation. 【Methods】 A total of 34 patients with postoperative bone nonunion for long bone shaft fracture, who were admitted and cured in the Orthopedics Department of our hospital from January 2019 to June 2020, were selected. They were randomly divided into the experimental group(n=17) and control group(n=17). Individuals in the control were treated with autologous iliac bone alone., while the experimental group were treated with autologous iliac bone graft plus autologous PRP during and after operation. After surgery, the autogenous PRP was accurately injected with ultrasound guidance every 7 days (5 mL/person, 4 occasions in total). The clinical healing time of the fracture, the grading of callus formation and the functional rehabilitation level of limbs on the affected side at different time were observed in both groups. 【Results】 All 34 patients were followed up. In the experimental group and the control group, the clinical healing time (month) of the fracture was (5.03±1.24) vs (6.91±1.41), P<0.05. The healing rate of the fracture for 6 months and 9 months was 94%(16/17)vs 59%(10/17)and 94%(16/17)vs 82%(14/17), respectively (P<0.05). The grading of callus formation within 3, 6 and 9 months was (2.11±0.69) vs (1.53±0.80), (3.06±0.90) vs (2.59±0.87) and (3.82±0.73) vs (3.35±0.86), respectively (P<0.05). The acceptance rate of functional rehabilitation of limbs on the affected side was 82.35%(14/17)vs 76.47%(13/17), P<0.05. 【Conclusion】 The application of autologous PRP in the treatment of postoperative bone nonunion for long bone shaft fractures during operation and after operation can achieve good clinical treatment.
