Analysis of influencing factors on re-entry of HBV DNA reactive blood donors
10.13303/j.cjbt.issn.1004-549x.2022.02.014
- VernacularTitle:郑州地区初筛HBV DNA反应性献血者归队影响因素分析
- Author:
Mingjun CHEN
1
;
Yifang WANG
1
;
Lumin YAN
1
;
Yueguang WEI
1
;
Tiantian TU
1
;
Lei ZHAO
1
;
Yonglei LYU
1
Author Information
1. Henan Red Cross Blood Center, Zhengzhou 450012, China
- Publication Type:Journal Article
- Keywords:
voluntary blood donor;
blood donor re-entry;
NAT;
HBV;
influencing factors
- From:
Chinese Journal of Blood Transfusion
2022;35(2):183-185
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the factors affecting NAT reactive blood donors re-entry, so as to provide data support for formulation of scientific and reasonable strategy. 【Methods】 The basic data and laboratory test results of 174 NAT reactive returning blood donors from January 2019 to August 2021 were collected and statistically analyzed by logistic regression. 【Results】 Among 174 HBV DNA reactive blood donors applying for re-entry, 81 (46.6%) were eligible for re-entry. Blood donation type and deconstructed Ct value were independent influencing factors of blood donors’ re-entry (P<0.05). The Ct value of minipool and deconstruction test showed significant affection on the re-entry (P<0.05). Donors with minipool-Ct-value exceeding deconstructed-Ct-value had a low likelihood of success with re-entry(P>0.05). No significant difference was observed in Ct values of deconstruction test, first re-entry test and second re-entry test (P<0.05). 【Conclusion】 In view of the low re-entry rate of NAT reactive blood donors, it is necessary to establish a set of safety criteria to lessen workloads. Donors with exceeding minipool-Ct-values, repeat reactive by two NAT reagents, failure in the first re-entry test are suggested to be deferred permanently.
