Study on blood donor deferral strategy by analyzing anti-TP test results
10.13303/j.cjbt.issn.1004-549x.2022.02.012
- VernacularTitle:基于抗-TP检测结果细化反应性献血者屏蔽策略的研究
- Author:
Jing SUN
1
;
Rui WANG
1
;
Zhengmin LIU
1
;
Jin GUO
1
;
Nan GAO
1
;
Junjie JIA
1
;
Hongwei GE
1
;
Ling LI
2
Author Information
1. Beijing Red Cross Blood Center, Beijing 100088China
2. Clinical Transfusion Research Center, Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Transfusion Adverse Reactions Chinese Academy of Medical Sciences
- Publication Type:Journal Article
- Keywords:
anti-TP reactive donors;
TPPA;
donor deferral strategy
- From:
Chinese Journal of Blood Transfusion
2022;35(2):176-179
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To discuss the reliability and applicability of the current blood deferral strategy concerning anti-TPreactive blood donors (by ELISA). 【Methods】 TPPA confirmatory test was performed on the samples routinely detected by two different anti-TP ELISA reagents(reagent 1 and reagent 2), and the test data of dual reagent reactive and one reagent reactive blood donors were analyzed to determine the possibility of true positivity. 【Results】 1 624 anti-TP reactive samples(by ELISA) were collected, among which 1 467 were dual reagent reactive, 77 were reagent 1 reactive, and 80 were reagent 2 reactive. TPPA results showed that the positive predictive value (PPV) of dual reactive samples was 85.48%. Samples with high S/CO value (reagent 1≥13 and/or reagent 2 >17) were more likely to be true positive, with the PPV at 98.56% (reagent 1) and 99.13% (reagent 2), respectively, which were significantly higher than that when the S/CO value was≥1. Among the samples reactive to one reagent, 2 were confirmed positive in reagent 1 and 3 in reagent 2, with the PPV at 2.60% and 3.75% respectively, and had no correlation with high S/CO value. 【Conclusion】 Dual-reagent reactive donors with high S/CO value showed high possibility of true positivity, therefore should be deferred. TPPA test is helpful to identify true positivity in one-reagent reactive donors. Confirmatory test and follow-up should be a supplement to the current blood donor deferral strategy to ensure blood safety.
