Related quality indexes of different common plasma products: A comparative study
10.13303/j.cjbt.issn.1004-549x.2021.10.022
- VernacularTitle:不同普通血浆制剂相关质量指标的对比分析
- Author:
Jing LAN
1
;
Nana PING
1
;
Yuan ZHANG
1
;
Peng PENG
1
;
Jin DING
1
;
Yali ZHANG
1
;
Na LIU
1
;
Hua XU
1
Author Information
1. Shaanxi Blood Center, Xi’an 710000, China
- Publication Type:Journal Article
- Keywords:
common plasma product;
plasma total protein;
coagulation factor Ⅷ;
fibrinogen;
quality standard
- From:
Chinese Journal of Blood Transfusion
2021;34(10):1144-1146
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the difference of total protein (TP) content, coagulation factor VIII (FⅧ) activity and Fib content in different common plasma products, and to further provide basis for the establishment and refinement of relevant quality standards of common plasma products. 【Methods】 Samples involved in the experiment included frozen plasma and cryoprecipitated frozen plasma derived from whole blood and eukocyte-depleted whole blood. The TP content determination was carried out by biuret method. The FⅧ activity (FⅧ: C) and Fib content were determined by coagulation method. 【Results】 The TP content( g/L) in frozen plasma and cryoprecipitated frozen plasma derived from whole blood and eukocyte-depleted whole blood were 59.64±4.78 vs 58.09±4.1 vs 52.20±3.57 vs 51.89±1.50, respectively, and the FⅧ: C( %) were 109.63±43.38 vs 27.06±7.09 vs 71.83±21.64 vs 21.66±3.86,, and the Fib content (g/L) were 2.19±0.39 vs 1.30±0.24 vs 2.04±0.37 vs1.22±0.15, respectively. There was a significant difference in TP content between other common plasma products (P<0.05) while similar between frozen plasma and cryoprecipitated frozen plasma derived from eukocyte-depleted whole blood (P>0.05). There was significant difference in FⅧ: C among four common plasma products (P<0.05). The Fib content of cryoprecipitated frozen plasma was significantly lower than that of frozen blood, and there was no significant difference in Fib content among other common plasma products (P>0.05). 【Conclusion】 The TP content and FⅧ: C of common plasma products are closely related to the initial blood and preparation process. It is suggested that the quality standard of common plasma products should be further refined, and the establishment of cryoprecipitated frozen plasma relevant quality standard and clinical indications should be considered.
