Clinical characteristics and risk factors of adverse reactions to blood transfusion in Chinese adults based on evidence-based medicine
10.13303/j.cjbt.issn.1004-549x.2021.10.015
- VernacularTitle:基于循证医学研究我国成人输血不良反应的临床特点及相关影响因素
- Author:
Hongke LI
1
;
Pengju LEI
1
;
Hongying HE
1
;
Tieta HOU
1
;
Jing XI
1
;
Xiaolong WEN
1
;
Yifan LI
1
Author Information
1. Department of Blood Transfusion, Affiliated Hospital of Gansu Medical College, Pingliang 74400, China
- Publication Type:Journal Article
- Keywords:
adverse transfusion reactions;
clinical characteristics;
risk factors;
meta-analysis
- From:
Chinese Journal of Blood Transfusion
2021;34(10):1117-1120
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To evaluate the clinical characteristics and risk factors of adverse transfusion reactions (ATR) in Chinese adults, and to provide evidence-based medical evidence for early prevention. 【Methods】 The controlled trial (CT) of risk factors for ATR in Chinese adults were collected through PubMed, Embase, Cochrane Library, CNKI, CMB, VIP and Wanfang database, and the retrieval time was from the establishment of those databases to January 31, 2021 Literature was selected and extracted by 2 researchers according to inclusion and exclusion criteria. Meta-analysis was performed by RevMan5.3 software. 【Results】 A total of 28 049 patients in 12 literature were included, 1 190 patients were included into the ART group and 26 859 into the non-ART group. Meta-analysis results showed that the incidence of ART was 1.63% (410/24 361), mainly allergic reaction (43.90%, 188/410) and non-hemolytic fever (40%, 164/410). Primary hematologic disease (OR=27.11, 95%CI=21.64~33.96, P<0.01), allergy history(OR=15.52, 95% CI=2.20~109.38, P<0.01), transfusion history(OR=9.36, 95% CI=7.77 ~11.28, P<0.01), numbers of blood transfusion > 2 (OR=7.06, 95% CI=5.64~8.84, P<0.01), >30 min interval between blood issuing and transfusion (OR=3.40, 95% CI=2.88~4.00, P<0.01), transfusion of plasma (OR=2.67, 95%CI=2.20~3.25, P<0.01) and cryoprecipitate (OR=1.43, 95%CI=1.21~1.68, P<0.01) were risk factors for ART, while the transfusion of red blood cells/white blood cells/platelets (OR=0.29, 95% CI=0.24~0.35, P<0.01) was the protective factor. Sensitivity analysis showed that the results were stable. 【Conclusion】 According to the correlation intensity, the risk factors for ART in Chinese adults from high to low are primary blood disease, history of allergy, transfusion history, numbers of blood transfusion >2, >30 min interval between blood issuing and transfusion, transfusion of plasma and cryoprecipitates, while transfusion of red blood cells/white blood cells/platelets was the protective factor.
