Effect of leukocyte-depleted suspended red blood cells storaged for different time on patients with hematologic diseases and malignant tumors
10.13303/j.cjbt.issn.1004-549x.2021.10.009
- VernacularTitle:血液病和恶性肿瘤患者输注不同贮存时间去除白细胞悬浮红细胞疗效分析
- Author:
Fengmian ZHAO
1
;
Ying CHANG
1
;
Xiaomin NIU
1
;
Jianhui LIU
2
;
Xiaoliang REN
3
;
Xiaoran ZHANG
4
;
Yanhua ZHANG
5
;
Cuiping AN
6
;
Zhiqin WANG
7
;
Jiangtao XING
8
Author Information
1. Hebei Province Blood Center, Shijiazhuang 050071, China
2. Hebei General Hospital
3. The Fourth Hospital of Hebei Medical University
4. Xinle City Hospital
5. The First Hospital of Xinji City
6. The First Hospital of Shijiazhuang
7. Shijiazhuang Luquan District People′s Hospital
8. Shijiazhuang Ping’an Hospital Co. Ltd.
- Publication Type:Journal Article
- Keywords:
leukocyte-depleted suspended red blood cells;
RBC storage time;
hematologic diseases;
malignant tumor;
transfusion efficacy
- From:
Chinese Journal of Blood Transfusion
2021;34(10):1094-1098
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the effect of leukocyte-depleted suspended red blood cells (lds-RBCs) storaged for different time on blood transfusion effect of patients with hematologic diseases and malignant tumors, as well as to evaluate the storage quality of lds-RBCs in blood stations. 【Methods】 Seven hospitals (4 tertiary-A hospitals and 3 secondary-A hospitals), applying for blood from our blood center, were selected. Blood transfusion cases (medical record) and related data (indicators) of patients with blood diseases and malignant tumors in those hospitals from December 2018 to May 2019 were collected, including disease diagnosis (type) before transfusion, demographic characteristics, date of solo transfusion of lds-RBCs, units of lds-RBCs [(1~2)U/bag, 1 U=200 mL whole blood], different storage duration (1~5 weeks) (bar code), and hemoglobin (Hb) 48 h before and after transfusion. The efficacy of lds-RBCs (storaged for different time) transfusion in patients with hematologic diseases and malignant tumors was evaluated by statistical analysis. 【Results】 A total of 3 557 patients with hematologic diseases and malignant tumors were enrolled in this study. No significant changes were noticed in transfusion efficacy by blood transfusion unit, gender and previous transfusion history (P > 0.05). The effective rate of lds-RBCs in patients with blood diseases and malignant tumors, stratified by storage duration, i. e. storaged for >1~2 weeks, >2~3 weeks, >3~4 weeks and more than >4~5 weeks, was 78.77% vs 77.68% vs 75.06% vs 70.37%, and 79.32% vs 76.73% vs 72.79% vs 67.65%, respectively(P<0.05), with lds-RBCs of 4-5 storage weeks presenting the lowest transfusion efficacy in both groups of patients. 【Conclusion】 The storage time of most lds-RBCs supplied by our center is moren than 3 weeks, and the transfusion effect of lds-RBCs stored for 5 weeks needs further observation. In order to ensure and improve the efficacy of blood transfusion, evidence-based medicine and information management are needed to help the clinical gasp the advantageous time of blood products and shorten the storage-to-transfusion time of red blood cells.
