Expression of ABO blood group antigen on platelets of blood donors
10.13303/j.cjbt.issn.1004-549x.2021.10.003
- VernacularTitle:献血者血小板表面ABO血型抗原表达强度分析
- Author:
Xia LING
1
;
Guangshu YU
1
;
Xianguo XU
1
Author Information
1. Blood Center of Zhejiang Province, Hangzhou 310052, China
- Publication Type:Journal Article
- Keywords:
platelets;
ABO blood group;
ABO-incompatible transfusion
- From:
Chinese Journal of Blood Transfusion
2021;34(10):1069-1072
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To study the expression level of ABO blood group antigen on the surface of platelets of blood donors. 【Methods】 A total of 506 donors with normal ABO blood group were selected to analyze the ABO antigen on platelets by flow cytometry. Among them, 30 donors were selected to monitor the changes of ABO antigen on platelets during the storage period, and the remaining 476 to analyze the expression difference of ABO antigen among blood donors. 【Results】 The ABO antigen on platelets of each sample fluctuated slightly but was relatively stable over 1~7 days in vitro. According to MFI values, the donors were divided into low-, moderate- and high- expression groups, with the average frequency of 59.6%, 35.5% and 4.9%, respectively. The A and B antigens of blood group AB platelets exhibited a competitive co-expression pattern. 【Conclusion】 Most individuals have low-expression phenotype of ABO antigen on platelets and can be potential platelet donors for ABO-incompatibility transfusion, which is helpful to improve platelets transfusion strategy.
